N-Desmethylclozapine-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEN-Desmethylclozapine(Standard)Cat.No.:HY-G0021RCASNo.:6104-71-8分子式:C??H??ClN?分子量:312.8作用靶點(diǎn):mAChR;OpioidReceptor;DrugMetabolite;VirusProtease作用通路:GPCR/GProtein;NeuronalSignaling;MetabolicEnzyme/Protease;Anti-infection儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性N-Desmethylclozapine(Standard)是N-Desmethylclozapine的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。N-Desmethylclozapine是非典型抗精神病有效劑Clozapine的主要活性代謝產(chǎn)物。N-Desmethylclozapine是一種有效的、變構(gòu)的部分M1受體激動(dòng)劑(EC50=115nM)，能通過M1受體激活增強(qiáng)海馬N-methyl-d-aspartate(NMDA)受IC50&TargetEC50:115nM(M1receptors)[1]δ-opioid[2]REFERENCESLiZ,etal.N-desmethylclozapine,amajormetaboliteofclozapine,increasescorticalacetylcholineanddopaminereleaseinvivoviastimulationofM1muscarinicreceptors.Neuropsychopharmacology.2005Nov;30(11):1986-95.OdagakiY,etal.ComparativeanalysisofpharmacologicalpropertiesofxanomelineandN-desmethylclozapineinratbrainmembranes.JPsychopharmacol.2016Sep;30(9):896-912SugawaraY,etal.Electrophysiologicalevidenceshowingmuscarinicagonist-antagonistactivitiesofN-desmethylclozapineusinghippocampalexcitatoryandinhibitoryneurons.BrainRes.2016Jul1;1642:255-62GigoutS,etal.DifferentpharmacologyofN-desmethylclozapineathumanandratM2andM4mAChRsinneocortex.NaunynSchmiedebergsArchPharmacol.2015May;388(5):487-96HimmerichH,etal.Impactofclozapine,N-desmethylclozapineandchlorpromazineonthromboxaneproductioninvitro.MedChem.2012Nov;8(6):1032-8.MedigeshiGR,etal.N-Desmethylclozapine,FluoxetineandSalmeterolinhibitpost-entrystagesofdengueviruslife-cycle.AntimicrobAgentsChemother.2016Aug29.1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820