Protoporphyrin-IX-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEProtoporphyrinIX(Standard)Cat.No.:HY-B1247RCASNo.:553-12-8分子式:C??H??N?O?分子量:562.66作用靶點(diǎn):EndogenousMetabolite作用通路:MetabolicEnzyme/Protease儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 ProtoporphyrinIX(Standard)是ProtoporphyrinIX的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。ProtoporphyrinIX是血紅素生物合成途徑中的最終中間體。ProtoporphyrinIX作為輻射敏化劑，即使在缺氧狀態(tài)下也能增強(qiáng)ROS的生成并誘導(dǎo)DNA損傷。ProtoporphyrinIX也作為光敏劑，通過(guò)光照射直接降解發(fā)生光漂白。ProtoporphyrinIX在給藥5-aminolevulinicacid(5-ALA)(HREFERENCESYasushiNakai,etal.ProtoporphyrinIXinducedby5-aminolevulinicacidinbladdercancercellsinvoidedurinecanbeextracorporeallyquantifiedusingaspectrophotometer.MyrzakhmetovB,etal.PhotophysicalPropertiesofProtoporphyrinIX,Pyropheophorbide-aandPhotofrin?inDifferentConditions.Pharmaceuticals(Basel).2021Feb9;14(2):138.TopeWD,etal.ProtoporphyrinIXfluorescenceinducedinbasalcellcarcinomabyoraldelta-aminolevulinicacid[J].PhotochemPhotobiol.1998Feb;67(2):249-55.vandenBoogertJ,etal.5-Aminolaevulinicacid-inducedprotoporphyrinIXaccumulationintissues:pharmacokineticsafteroralorintravenousadministration[J].JPhotochemPhotobiolB.1998Jun15;44(1):29-38.LiC,etal.G-quadruplexessensenaturalporphyrinmetabolitesforregulationofgenetranscriptionandchromatinlandscapes.GenomeBiol.2022Dec15;23(1):259.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>