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胡桃醌體內(nèi)抗腫瘤作用研究崔蘭1A12，曲中原1A12，鄒翔1A12，胡國軍1A12，季宇彬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,QUZHONGYUAN1A1542,ZOUXIANG1A1542,HUGUOJUN1A1542,JIYUBIN1A15421ENGINEERINGRESEARCHCENTEROFNATURALANTINEOPLASTICDRUGSA155MINISTRYOFEDUCATION,HARBIN150076,CHINA2CENTEROFRESEARCHANDDEVELOPMENTONLIFESCIENCESANDENVIRONMENTALSCIENCES,HARBINUNIVERSITYOFCOMMERCE,HARBIN150076,CHINAABSTRACTOBJECTIVEINTHISEXPERIMENT,THEANTITUMOREFFECTSOFJUGLONEWASSTUDIEDONTUMORMICEMETHODSTHEGRAFTMOUSETUMORMODELS180WASUSEDTOINVESTIGATETHEEFFECTSOFJUGLONEONTUMORGROWTHANDTHEWEIGHTSOFIMMUNEORGANSAFTERHESTAINING,THEGROWTHANDPATHOMORPHOLOGICCHANGESOFTUMORCELLSWEREOBSERVEDBYOPTICALMICROSCOPETHEGRAFTMOUSETUMORMODELH22WASUSEDTOINVESTIGATETHEEFFECTSOFJUGLONEONSURVIVALTIMERESULTSTHEINHIBITORYRATEOFJUGLONEATTHEDOSAGEOF025,05AND1MGKG1D1WAS1709,2212,2961RESPECTIVELYTHEINHIBITORYRATEOFJUGLONEATTHEDOSAGEOF05,1MGKG1D1WASSIGNIFICANTLYINCREASEDCOMPAREDWITHTHECONTROLGROUPP001SPLEENINDEXIN05,1MGKG1D1DOSAGEGROUPHADSIGNIFICANTDECREASEP005,P001,ANDTHYMUSINDEXHADNOCHANGEUNDERTHEOPTICALMICROSCOPE,THEDEGREEOFCELLNECROSISOFJUGLONEGROUPINCREASEDSIGNIFICANTLYCOMPAREDWITHTHECONTROLGROUPTHELIFEPROLONGATIONRATEOFJUGLONEATTHEDOSAGEOF025,05AND1MGKG1D1WAS7388,8209,9925RESPECTIVELY,WHICHWASSIGNIFICANTLYINCREASEDCOMPAREDWITHTHECONTROLGROUPP005CONCLUSIONJUGLONEHASCONSPICUOUSANTITUMOREFFECTSINVIVOJUGLONECANINHIBITETHEGROWTHOFSARCOMAGRAFTSOFS180MICEANDA156A157A158A159A160A161A162A163A164A165A166A167A168A169A170A171A172A173A174A173A173A175A176A174A177A178A179A180A166A181A182A183A184A166A165A184A185A169A165A186A167A168A187A188A173A173A174A173A188A189A173A173A173A176A190A191A192A193A194A195A160A196A1971982,A198,A199A183,A186A200A201A202A160A203A204A205A206A207A208A209EMAILLLXXCL163COMTEL/FAXA210045184866922PROLONGTHELIFETIMEOFH22MICEEFFECTIVELYKEYWORDSJUGLONEANTITUMOREFFECTSS180H22A211A212A213JUGLONEA214A215A213A216A217A218A2195A220A2211,4A215A213A222A223A224A225A226A227A228A211A212A229A230A231A232A223A233A234A235A236A237A235A238A239A237A240A241A242A243A244A245A246A247A248A2491A2503A251A252A253A254A248A255A252A253A12A0A1A2A3A4A235A238A239A5A61A20A124A4A235A238A239A248A249A11A6A7A8A9A10A13A251A132A14A134S180A24A239A15A16A17H22A24A239A15A16A255A18A19A20A135A21A239A22A237A30A23A25A26A237A35A27A25A26A237A51A28A29A31A22A245A25A120A32A238A239A79A33A244A34A138A46A36A139A37A20A38A252A253A254A4A39A40A235A238A239A248A249A141A41A143A42A43A44A45A251A471A48A49A50A49A50A52A53A54A55A56A53A54A55A56FIG1CHEMICALSTRUCTUREOFJUGLONE1材料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方法21A35A36A37A35A36A37A38A38S180A40A41A42A43A44A45A41A40A41A42A43A45A41A45A41A46A47A46A47A46A75A48A49A50A59A51A5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