醫(yī)藥信息檢索實習報告

1、項目名稱（中文）支氣管哮喘疾病的發(fā)病機制項目名稱（英文）the pathogenesis of bronchial asthma姓名專|（ 中藥學學號一、目的：支氣管哮喘已經成為現(xiàn)代社會的高發(fā)病、多發(fā)病，其發(fā)病率和病死率有 逐年上升的趨勢。支氣管哮喘的發(fā)病機制極為復雜，涉及許多方面，到目前為止其發(fā)病 機制尚未完全闡明。次檢索是為了深入了解支氣管哮喘疾病的發(fā)病原因和機制，給支氣 管哮喘的預防與治療提供科學的依據(jù)。二、檢索項目的科學技術要點1支氣管哮喘的背景課題背景資料的了解途徑：數(shù)據(jù)庫：中國知網，cbm網上資源：百度支氣管哮喘已經成為現(xiàn)代社會的高發(fā)病、多發(fā)病，其發(fā)病率和病死率有逐年上升的 趨勢。

2、支氣管哮喘以反復性、發(fā)作性的呼吸困難為表現(xiàn)，氣道慢性炎癥、氣道高反應性 和可逆性氣道阻塞是其特點，并且具有長期性、周期性、和反復性，難以治愈，因此闡 明支氣管哮喘的發(fā)病機制，對于尋找更有效的治療方式非常重要。支氣管哮喘的發(fā)病機制極為復雜，涉及許多方面，到目前為止其發(fā)病機制尚未完全 闡明?？赡芘c遺傳因素、環(huán)境因素、免疫學機制、神經機制等有關。其中，哮喘與免疫 的關系己經成為研究重點。體內肥大細胞、嗜酸粒細胞(eos)和t淋巴細胞等免疫活性 細胞在某種因素刺激下被激發(fā)，在它們分泌的細胞因子等的作用下發(fā)病。細胞因子是免 疫活性細胞的效應因子，其免疫調節(jié)功能在哮喘發(fā)病機制中處于中心地位。哮喘的發(fā)病從免

3、疫學角度可以分為三期：初期為致敏階段，包括過敏原刺激、t細胞 激活、ige合成和效應細胞釋放介質，b7/cd28和cd69在這一過程也扮演重要角色； 第二期為慢性過敏性炎癥階段，th1/th2失衡導致免疫功能紊亂是此階段的主要原因, 在哮喘發(fā)作過程中起主要作用；第三期為慢性炎癥引起的氣道結構重構階段，是難治性 支氣管哮喘的重要發(fā)病和死亡原因。三、檢索點與檢索要求檢索點：:中文：支氣管哮喘；發(fā)病機制:英文：bronchial asthma； pathogenesis文獻檢索數(shù)據(jù)庫生物醫(yī)學文獻庫（cbm）（1）高級檢索檢索年限：2004-2014檢索途徑：高級檢索檢索詞:支氣管哮喘，發(fā)病機制邏輯檢

4、索表達式：（”支氣管哮喘”常用字段:智能）and”發(fā)病機制”常用字段:智能檢岀文獻總數(shù)：1489中國生物醫(yī)學文獻數(shù)據(jù)庫衷檢索 高級檢索主題檢索分類檢索期刊檢索作者檢索 機構檢索基金檢索弓i（支氣管哮喘）and “發(fā)病機制“常用宇段：智能（3檢索苛清除限走卷構建表達式：常用字段/智能檢索 and 匕限定條件：2004-2014;年代 2004 立到2014 二 i清除檢索年限：2004-2014檢索途徑：高級檢索檢索詞：支氣管哮喘，發(fā)病機制邏輯檢索表達式：（”支氣管哮喘”標題）and “發(fā)病機制”標題 檢出文獻總數(shù)：44乂中國生物醫(yī)學文獻數(shù)據(jù)庫快速檢索 高級檢索主題檢索分類檢索期刊檢索作者檢索

5、機構檢索基金檢索i(支氣管哮喘)and "發(fā)病機制"中文標題：智能廚檢索命唐除，限亍構建表達式：中文標題"智能檢索and |限走條件：2004-2014； 年代 兇04| j3到2014 j 清除j檢出文獻題錄：ih 丁輝;劉璽誠神經營養(yǎng)因子在支氣管哮喘發(fā)病機制中作用的研究進展j國際兒科學雜志,2007,34(1):53-552.2楊靜；王曉蕾；張秋業(yè).支氣管哮喘發(fā)病機制的研究進展j.中國醫(yī)藥,2007,2(8):511-512.徐軍.支氣管哮喘發(fā)病機制研究新進展j沖華結核和呼吸雜志,2007,30(7):490-493.(2)專業(yè)檢索：主題樹呼吸道疾病支氣管疾病

6、哮喘哮喘，運動誘發(fā)性哮喘持續(xù)狀態(tài)序號命中文獻數(shù)檢索表達式#321(#1) and (#2) and 2004-2014日期#2711”哮喘/病因學/中1矢病機嚇不加權:擴展6562中國期刊全文數(shù)據(jù)庫(cnki-cajd)檢索年限：2004-2014檢索途徑：專業(yè)檢索檢索詞：支氣管哮喘，發(fā)病機制 邏輯檢索表達式：su二支氣管哮喘*發(fā)病機制檢岀文獻總數(shù)：1098文獻分類目錄公擇學科領域循除0 基礎科學o 工程科技1 ise) 工程科技】1輯0 農業(yè)科技9間醫(yī)藥衛(wèi)生科技0 底藥衛(wèi)生方計政策與法律法規(guī) 研究0 更學教自與醫(yī)學邊煤學科0 ams學與衛(wèi)生學(3 中醫(yī)學o 中藥學(3 中西匡結臺s 基疏巨學

7、s 臨超學s 感染性疚病及傳衆(zhòng)病s 心血管奚統(tǒng)疾病0 a乎吸系統(tǒng)病e)系統(tǒng)疾病e) 內分泌腺及全身性疾病e) 口外科字0 泌尿科學 *%z高級檢索專業(yè)粉索作者發(fā)文檢素科研基全檢素句子檢索文獻來源檢素忘文氣笆發(fā)病機制槍索表達式語法發(fā)裘時從到2014-12-25可檢秦宇段su=主題丁匸題名ky二關註詞.ab二摘毀尸仁全文au=作直f匸第一責仔人afmr梅jn二文猷來源rf老考文獻，ye=.fu=ffi,cl 團分矣號.sn=issn.cn0充一刊號ib=isbn cg破引頻次示®1：1 > tu生態(tài)and ky二生態(tài)文明and (au %陳王)可以德素到篙名包括生態(tài)笄且關健訶也括生

8、態(tài)文明并且作肴為陳姓和王姓e 有文章)2su二寸匕京輿運餌d匚了二環(huán)境保護可以檢素到主題包括北st及輿運井且全文:中辺括環(huán)愼保護的信息；3su二(經濟岌風-pj持繆發(fā)展丁轉更泡沬'可檢索經濟發(fā)展或可拎線發(fā)展肖關轉交的信建，并且可以去除與泡沫有關的部分卩分組述覽來源數(shù)狛庫學科發(fā)衰年度研究:層次作奢機構荃金免麥訂間走制檢2014(65)201x131)2012(130)2005(51)2004(75)2011(122)2010(101)2009 109)2008 83)2007(98)2006(123)排： w岌裏旳間祓引下裁找到1,098條結果測菟”55 7切検到薊55 甜頁記錄數(shù)：10

9、|(0)荷除導岀/瑩考文獻分析/問瀆題名作者來源發(fā)表時間數(shù)據(jù)庫彼引下截預覽 1支氣昔哮喘發(fā)病機制研究逬展日砂：刁陜:用：弓長匡竺爐話 湘蕪；王匡子碇tata2009-08-05期刊 34星1790 q7調整檢索:檢索年限：2004-2014檢索途徑：專業(yè)檢索檢索詞：支氣管哮喘，發(fā)病機制邏輯檢索表達式：ti=“支氣管哮喘呼“發(fā)病機制”檢出文獻總數(shù)：66文獻分類目錄決壬擇學科領域全迭 満隊0eb5s科學(3叼工程科技】輯13叼工程科技i】信田叼農業(yè)科技田叼醫(yī)藥衛(wèi)生科技田叼哲學與人文科學s叼社會科學】懾田叼社會科學i】館(3叼信息科技田叼經濟與ttsh¥盤級檢當作舍發(fā)文檢家科研se全檢索句

10、子檢室文慰來源檢家專業(yè)柏牽ti= “支氣楚啤味勺八發(fā)病機創(chuàng)j發(fā)夷時目：從：到 2014-12-25栓累黑達武語法建杲中拾第可檢窒寧段su二主題=題名關謹同,asm要ft=全文au二作者fi二第一貴任人,af二機構jn二刃«來線rf龍考文紙，ye=.fu=s金,clc： 囹分類號.sn二issn.cn冷一刊號ib二isbn ,cf=w引頻次示區(qū)1) tu生態(tài)and ky生奄文明，arxl (au % 陳"王)可以檢素到倉名包括生態(tài)并且關減詞色括生態(tài)文明笄且作者為磁址和王'姓的f 有文章；2) su二dl5jt輿運and ft二環(huán)境保護'可以檢素到主塹包痞t涼衣

11、典運笄且全文中包括壞境保護的信亙；3) su=(經濟左霧可持續(xù)發(fā)靈體爰泡沫可檢索經磁恵或可待續(xù)發(fā)縣有關菇支的信息，并且可以去除與泡沫'有關的祁分軌文獻來源y中華結核和呼吸*志分組瀏覽來源埶援庫學科 發(fā)裘年廈 硏究層次作畫機構基全免費訂閱定刮撿索2014(9)2004(7)2013(6)2012(9)2011(10)2010 20094)20082007(4)2006 5)20053：排啟發(fā)表時間被引下戲切癬»要每頁記錄如ic e中華醫(yī)學會第五次:(3)影導出/垂考又販分祈/閱讀檢出文獻題錄:題名r作者莊來源發(fā)表時間數(shù)抿產條件：題名=支氣訓喘”發(fā)病機制并且發(fā)表a寸間betwee

12、n (20044jw1.2014-12-25)(精確匹配)01支氣管哮喘免疫學發(fā)病機制的研究進展上富丈姬:沈感鳳上海交通大學學報(氏 字版)20095-15期刊02支氣管哮喘發(fā)病機制的研究進展李字良:許朝霞王憶勒中華中醫(yī)藥宇刊2012-09-10期刊03支氣管哮端發(fā)病機制研究進展白歇刁絃暴張湘薫:王玲玲醫(yī)探述2009-08-05期刊|上官文姬;沈惠風.支氣管哮喘免疫學發(fā)病機制的研究進展兒上海交通大學學報(醫(yī)學版),2009,5(29):602-606.2李學良；許朝霞；王憶勤支氣管哮喘發(fā)病機制的研究進展j中華中醫(yī)藥 干ij, 2012,9(30). 白敏；刁曉源；張湘燕；王玲玲支氣管哮喘發(fā)病機

13、制研究進展j.醫(yī)學綜 述,2009,15(15):2294-2297.(二)檢索國外下列有關外文數(shù)據(jù)庫1. pubmed檢索年限：2004-2014檢索詞：bronchial asthma； pathogenesis邏輯檢索表達式：(bronchial asthmatitle/abstract) and pathogenesisftitle/abstract檢出文獻總數(shù)：301% ncb1 resources © how to 匕pub血ed腫us national library of medicine national ottleaftk-article typesclinica

14、l trialreviewcustomize.pubmed(bronchial asthmafntle/abstractl) and pathoaenesistitle/abstracto rss save search advanceddisplav sellings; summary. 20 per page sorted by recently addedresults: 1 to 20 of 301page 1send to: eof 16 next > last»text availabilityabstractfree full textfull textpubli

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16、2014.12 004 epub ahead clearof pnnt； review.pmid. 25511380 pubmed as supplied by publisher、一 thrombomodulin inhibits the aclivaiion of eosinophils and mast cells2 roeen z toda m d'alessandro-gabazza cn omsni m kobayashi t yasuma t urawa m taguchlo gabazza eccell immunol 2014 dec 5:293(1 34-40 do

17、i: 10.10l6.cellimm.2014.11.005. epub ahead of print*pmid: 25497974 pubmed - as supplied by publisher)clear all調整檢索:檢索年限：10 years檢索詞： 支氣管哮喘，發(fā)病機制邏輯檢索表達式：(bronchial asthmatitle) and pathogenesistitle檢岀文獻總數(shù)：25pub 牴ed.gouus national library of medicine national institutesofaealtharticle typesreviewcustom

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19、t;< first <pre page of 2 next>o filters activated published in the last 10 years. clear all to show 196 itemsbronchial asthma pathogenesis and generic drognosis develodmen1 balmasova ip sepiashvill rl sepiashvili lar malova esclearzh mikroblol epidemiol immunodiol. 2014 may-jun:(3):60-7. re

20、view. russian.pmid: 25286513 pubmed -indexed for medlinerelated citationsroles of envionmental factors in【he dathog©n”is of bronchial asthma2 zhao h. chen pzhonghua yl xue za zhl. 2014 apr 29:94(16):1204-6. chinese no abstract availablepmid: 24924880 pubmed -in processrelated citationshistorydo

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22、ished in the last 10 years301#1addsearch (bronchial asthmaftitle/abstract) and pathogenesistitle/abstract1012檢出文獻題錄：1 balmasova ip, sepiashvili ri, sepiashvili iar, malova es.bronchial asthma pathogenesis and genetic prognosis developmentj.zh mikrobiol epidemiol immunobiol. 2014,9(3):60-7. 21 zhao h

23、, chen p. roles of environmental factors in the pathogenesis of bronchial asthmaj. zhonghua yi xue za zhi. 2014,94(16):1204-1206.3 gvetadze lg kavtaridze gv, kvachadze tk.psychosomatic mechanism in pathogenesis bronchial asthma and ulcerous diseasejj .georgian med news. 2013(225):78-81.五檢索總結支氣管哮喘(簡稱

24、哮喘)是一種由多因素引起的以可逆性氣道阻塞、氣道高反應性和 氣道炎癥為特征的免疫變態(tài)反應性疾病，其屮以氣道炎癥為最主要的病理變化，并決定 氣道阻塞和氣道高反應性的程度。經國內外研究表明哮喘的發(fā)病機制極為復雜，thl /th2失衡、gata-3轉錄因子、cd4+cd25+調節(jié)性t細胞、瘦素、黏膜免疫的下降等 都參與了哮喘的免疫機制，神經因子等參與哮喘的神經機制，遺傳因素目前已將哮喘候 選基因粗略定位，進一步向蛋口質組學發(fā)展，但仍未明確。隨著人們對哮喘病認識的不斷深入，治療的重點已從單純緩解氣道平滑肌痙攣，轉 為以預防、防治為主的綜合治療。在治療上，醫(yī)者們應注意中西醫(yī)結合，采取多靶點、 多環(huán)節(jié)的治

25、療方案，這樣才能達到事半功倍的效果。通過更多地開展哮喘危險因素的調 查研究，從群體水平上對疾病進行有效的控制和預防，減少支氣管哮喘的患病率及死亡 率。pubmed實習1 利用“advance search”檢索有關“支氣管擴張劑(bronchodilators)治療兒童哮喘(asthma),9(限題名/文摘字段)的綜述文獻，且有免費全文(2002-2012年)。therapyxtreatment treat cure 作業(yè)要求記錄檢索式：search (bronchodilatorstitle/abstractl) and asthmatitle/abstract) and (therapy

26、or treatment or treat or curetitle/abstract) filters: review; free full text available;publication date from 2002/01 /01 to 2012/12/31; child: birth-18 years 在上題命中的記錄中選前兩條，加入剪貼板，并以abstract摘要格式查看。results： 1 to 20 of 84 selected 2« first < prevfilters activated review free full text published

27、in the last 10 years child 63475 items.choose destination_ file'©collections1o order1citation manager clipboarde-mailmy biblio屮1.how have advances in our understanding of the molecuiar genetics c improved targeted therapies for these diseases。szychot e, brodkiewicz a, peregud-pogorzelski ja

28、dv clin exp med. 2014 may-jun:23(3):469-74. review.pmid: 24979521 pubmed - indexed for medline free articlerelated citatio nsadd 2 items.add to clipboardv efficacy of 5nitroimidazoles for the treatment of giardiasis a systematic review of randomized2 con trolled trials.pasupuleti v. escobedo aa. des

29、hpande a. thota p. roman y. hernandez av.plos negl trop dis. 2014 mar 13;8(3):e2733. doi: 10.1371/journal.pntd.0002733. ecollection 2014 mar. review.pmid: 24625554 pubmed indexed for medline free pmc articlerplatpd ritatinns%如 clin exu llec 2014 l.lay-jun;23(3):469-74_how have advances in our unders

30、tanding of the molecular genetics of paediatric leukaemia led to improved targeted therapies for these diseases?sz/cfiot . brodklewicz pereaud-poaorzelski j?© author informationabstractthe term "bukagmia” refers to a large and heterogenous group of diseases with treatment response and outc

31、ome dependent on the specific type of malignancy. new molecular methods allow us to specrfically evaluate the type of disorder and provide treatment of necessary intensity the aim of this reviesv is to provide insight into the progress in leukaemia treatment that had been possible due to advances in

32、 molecular gmnetics over the last few decades those new sophisticated diagnostic methods have allowed us not only to predict patients* prog nosis but also to provide a specific therapy depending on the molecular and genetic characteristics of patients our review is based on 25 articles regarding nov

33、el diagnostic and therapeutic methods as well as prognostic factors released between 1992 and 2011 those articles focus mostly on molecular and cytogenetic testing alloving fevolutionary methods of patient classification and individual therapy for this highly heterogeneous group of disorders impleme

34、ntation of molecular genetic testi ng to evaluate the type of leukaemia allowed paediatnc on cologists and haematologists to adjust the in tensity of treatment improve outcome minimize toxicity of therapies and considerably lower the nsk of side effects in the last few decades there has been a great

35、 improvement in survival among children suffering from haematopoietic malignancies progress made in molecular genetics allovied the creation of new treatment protocols that are designed to maintain a high cure rate for children with leukaemia while reducing toxicitypmid: 24979521 publ.led indexed fo

36、r medline free full textitem in clipboardn > siabstract ©send to: © (plosneai tro。dis 2014 mar i3:8(3):e2733. dot: 10 1371/journal pntd 0002733 ecollection 2014|efficacy of 5-nitroimidazoles for the treatment of giardiasis: a systematic review of randomized controlled trials.pasupuleti.

37、escobedo aa® deshpandethotap.roman y4*.hernandezav.c author informationabstractbackground: giardiasis is one of the most common causes of diarrheal disease worldwide and 5-nitroimidazoles (5-ni) are the most comm only presenbed drugs for the treatment of gi合rdiasis we evaluated th© efficac

38、y of 5-nitroimidazolgs (5-ni) in the treatment of giardiasis in a system合ticpreview of randomized controlled trials (rcts).包methodology/principal findings: we conducted a compcehensrve literature search in pubmed-medline scopus web of science and cochrane library for rcts evaluating the efficacy of

39、5-ni vs control (placebo or acti treatment) on parasitological cure in patients with parasitologically-demonstrated giardiasis the search was performed in may 2013 with no language restriction by tv/o authors independently. the " efficacy outcome was parasitological cure and harmful outcomes we

40、re abdominal pain bitter or metallic taste and headache we in eluded 30 rcts (n = 3.930). there was a significant and slightly higher response rate with 5-ni in giardiasis treatment (rr 1.06. 95%c11.02-1.11. p=0.005). there was e high heterogeneity among studies (12=72%) the response rates for metro

41、nidazole lin泌azole and secnidazole were similar (rr 1 05 95%ci 1 01-91 09, p=0 01; rr 1 32 95%ci 1 10-1 59, p=0 003; and rr 1 18 95%ci 0 93-1 449 p=0 18 respectrvely) on subgroup analyses, the response rates / did not vary substa ntially and high heterogeneity persisted (i2=57%-8o%). harmful outcome

42、s were un comm on. and 5-nls were associated with lower s risk of abdominal pain, and higher risk of both bitter or metallic taste and headache&conclusions: studies investigating the efficacy of 5-ni in giardiasis treatment are highly heterogeneous. 5-nls have a slightly better efficacy and s wo

43、rse profile for mild harmful outcomes in the treatment of giardiasis in comparison to controls larger high quality rcts are needed to further assess efficacy and safety profiles of 5-nipmid 24625554 pubmed -indexed for medline pmcid pmc3953020 free pmc articleitem in clipboard.h > siff2詳盡檢索策略中“so

44、mnambulism”mesh terms中什么詞，其對應的自由詞（關鍵詞）是什么？“somnambulism”是主題詞，對應的自由詞是sleep walking causes3檢索2004-2007年發(fā)表的，膽結石cholelithiasis的文獻。檢出文獻的語種為英語，且全文免費的綜述文獻。要求：記錄檢索式search "cholelithiasis"mesh alters: review; free full text available; publicationarticle types < reviewcustomize.text availabilitya

45、bstract/ free full textfull textpublication dates10 yearst from 2004/01/01 to2007/12/31specieshumansother animalslanguagesf englishcustomize agesadult 19-44 yearsmiddle aged: 45-64 yearsaged: 65+ yearsdate from 2004/01/01 to 2007/12/31; englishpubmedwcholelithiasislmesh|us national ubrary of medicin

46、e nationals rss save search advancedinstitutes offlealfdear summary. 20 per page. sorted by recently added ©send to: ©results： 1 to 20 of 28«first < pre*. page of 2 nexi> last»dearo filters activated review free full text publication date from 2004/01/01 to 2007/12/31 engli

47、sh clear all to show 32675 itemsbile and dancreatic iuice exclusion activates acinar stress kinases and exacerbates gallstoneclear 1. dancrealitissamuel i.surgery. 2008 l.lar 143(3):434-40 doi: 10.1016ij.surg.2007.06.004. epub2007 dec21 review.pmid: 18291265 publ.led-indexedfor medline free pmc arti

48、clerelaled citationsutility of endoscodic ultrasound in dan creates a review2 rizk mk. gerke h.dearworld j gastroenterol 2007 dec 21:13(47):6321-6 reviewpmid: 18081219 publ.led indexed for medline free pmc articlerelated citationsrole of endoscopic retrograde choiangiooancreatogradhy in acute dancreatitis3- canlas kr. branch msworld j gastr