Thrombopoietin-Receptor-Agonists-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html Thrombopoietin HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html ReceptorThrombopoietin (TPO) is the major regulator of megakaryocytopoiesis and pla

2、telet formation. The protein encoded by the c-mplgene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellularcytokine receptor box motifs. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosinekin

3、ases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosinephosphorylated.TPO binds to the thrombopoietin receptor (TPOr, also termed c-mpl) on platelets, megakaryocytes, and pluripotent stem cellsleading to inhibition of apoptosis of stem

4、cells and megakaryocytes; increased megakaryocyte number, size, and ploidy; increasedrate of megakaryocyte maturation and platelet count; and decreased platelet threshold for activation by ADP and collagen.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html Thrombopoiet

5、in HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html Receptor HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Thrombopoietin Receptor.html Agonists HYPERLINK h

6、ttps:/www.MedChemE/e-z-eltrombopag-13c.html (E/Z)-Eltrombopag HYPERLINK https:/www.MedChemE/e-z-eltrombopag-13c.html HYPERLINK https:/www.MedChemE/e-z-eltrombopag-13c.html 13C4(E/Z)-SB-497115 13C4) Cat. No.: HY-15306S HYPERLINK https:/www.MedChemE/avatrombopag.html Avatrombopag(AKR-501; E5501; YM477

7、) Cat. No.: HY-13463(E/Z)-Eltrombopag 13C4 (E/Z)-SB-497115 13C4) is amixture complex of E-Eltrombopag andZ-Eltrombopag, with 13C labeled. Z-Eltrombopag isa thrombopoietin (TPO) receptor agonistdeveloped for certain conditions that lead tothrombocytopenia.Avatrombopag (AKR-501) is an orally active,no

8、npeptide thrombopoietin (TPO) receptoragonist (EC =3.3 nM). Avatrombopag mimics the50biological activities of TPO.Purity: 97.0%Clinical Data: No Development ReportedSize: 1 mgPurity: 98%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/avatrombopag-hyd

9、rochloride.html Avatrombopag HYPERLINK https:/www.MedChemE/avatrombopag-hydrochloride.html HYPERLINK https:/www.MedChemE/avatrombopag-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/avatrombopag-hydrochloride.html (AKR-501 hydrochloride; E5501hydrochloride; YM477 hydrochloride) Cat. N

10、o.: HY-13463B HYPERLINK https:/www.MedChemE/avatrombopag-maleate.html Avatrombopag HYPERLINK https:/www.MedChemE/avatrombopag-maleate.html HYPERLINK https:/www.MedChemE/avatrombopag-maleate.html maleate(AKR-501 maleate; E5501 maleate; YM477 maleate) Cat. No.: HY-13463AAvatrombopag (AKR-501) hydrochl

11、oride is an orallyactive, nonpeptide thrombopoietin (TPO)receptor agonist (EC =3.3 nM). Avatrombopag50hydrochloride mimics the biological activities ofTPO.Avatrombopag maleate (AKR-501) is an orallyactive, nonpeptide thrombopoietin (TPO)receptor agonist (EC =3.3 nM). Avatrombopag50maleate mimics the

12、 biological activities of TPO.Purity: 98.53%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/avatrombopag-d8-hydrochloride.html Avatrombopag-d8 HYPERLINK https:/www.MedChemE/avatrombopag-d8-hydrochloride.html

13、HYPERLINK https:/www.MedChemE/avatrombopag-d8-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/avatrombopag-d8-hydrochloride.html (AKR-501-d8 hydrochloride;E5501-d8 hydrochloride; YM477-d8 hydrochloride) Cat. No.: HY-13463BS HYPERLINK https:/www.MedChemE/Eltrombopag.html Eltrombopag(SB

14、-497115) Cat. No.: HY-15306Avatrombopag-d8 (hydrochloride) is deuteriumlabeled Avatrombopag (hydrochloride). Avatrombopag(AKR-501) hydrochloride is an orally active,nonpeptide thrombopoietin (TPO) receptor agonist(EC50=3.3 nM). Avatrombopag hydrochloride mimicsthe biological activities of TPO.Eltrom

15、bopag (SB-497115) is a thrombopoietin(TPO) receptor agonist developed for certainconditions that lead to thrombocytopenia.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.82%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Eltromb

16、opag-Olamine.html Eltrombopag HYPERLINK https:/www.MedChemE/Eltrombopag-Olamine.html HYPERLINK https:/www.MedChemE/Eltrombopag-Olamine.html Olamine HYPERLINK https:/www.MedChemE/Eltrombopag-Olamine.html HYPERLINK https:/www.MedChemE/eltrombopag-d9.html Eltrombopag-d9(Eltrombopag diethanolamine salt;

17、 SB-497115GR) Cat. No.: HY-15306A (SB-497115-d9) Cat. No.: HY-15306S1Eltrombopag Olamine (Eltrombopag diethanolaminesalt) is a thrombopoietin-receptor agonist usedto treat low blood platelet counts with chronicimmune thrombocytopenia.Eltrombopag-d9 (SB-497115-d9) is the deuteriumlabeled Eltrombopag.

18、 Eltrombopag (SB-497115) is athrombopoietin (TPO) receptor agonistdeveloped for certain conditions that lead tothrombocytopenia.Purity: 99.96%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/h

19、etrombopag.html Hetrombopag HYPERLINK https:/www.MedChemE/hetrombopag.html HYPERLINK https:/www.MedChemE/Lusutrombopag.html LusutrombopagCat. No.: HY-122620(S-888711) Cat. No.: HY-19883Hetrombopag is a potent thrombopoietinreceptor agonist. Hetrombopag is efficacious andwell tolerated with a managea

20、ble safety profile.Hetrombopag has the potential for the research ofimmune thrombocytopenia.Lusutrombopag is an orally bioavailablethrombopoietin (TPO) receptor agonist, usedfor treatment of chronic liver disease.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.32%Clinical

21、 Data: LaunchedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/lusutrombopag-d13.html Lusutrombopag-d13(S-888711-d13) Cat. No.: HY-19883S HYPERLINK https:/www.MedChemE/rafutrombopag.html RafutrombopagCat. No.: HY-145589Lusutrombopag-d13 is deuterium labeledLusutrombopag. Lusutrombopag is an orallybioavailable thrombopoietin (TPO) receptoragonist, used for treatment of chronic liverdisease.Rafutrombopag is a thrombopoietin (TPO)agonist extracted from patent CN113929668 A