Omarigliptin-MK-3102-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOmarigliptinCat. No.: HY-15981CAS No.: 1226781-44-7Synonyms: MK-3102分式: CHFNOS分量: 398.43作靶點(diǎn): Dipeptidyl Peptidase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO

2、: 50 mg/mL (125.49 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5099 mL 12.5493 mL 25.0985 mL5 mM 0.5020 mL 2.5099 mL 5.0197 mL10 mM 0.2510 mL 1.2549 mL 2.5099 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的

3、作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.27 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.27 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 M

4、aster of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.27 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Omarigliptin(MK-3102)DPP4效選擇性抑制劑，IC50值為1.6nM。REFERENCES1. Biftu T, et al. Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem.2014 Apr 24;57(8):3205-12.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax