E3-ligase-Ligand-Linker-Conjugates-7 _E3 Ligase Ligand-Linker Conjugate - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEE3 ligase Ligand-Linker Conjugates 7Cat. No.: HY-103604CAS No.: 2064292-52-8分式: CHClNOS分量: 700.29作靶點(diǎn): E3 Ligase Ligand-Linker Conjugate作通路: PROTAC儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2

2、O : 50 mg/mL (71.40 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.4280 mL 7.1399 mL 14.2798 mL5 mM 0.2856 mL 1.4280 mL 2.8560 mL10 mM 0.1428 mL 0.7140 mL 1.4280 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 E3 ligase Ligand-Linker Conjugates 7種合成化合物，

3、包含 E3 泛素連接酶配體與 PROTAC 連接物，可以將靶蛋與泛素化機(jī)制結(jié)合起來(lái)。詳細(xì)信息請(qǐng)參考專(zhuān)利獻(xiàn) US20170008904A1 中 Example 3 中合成化合物A1895 的具體步驟 1。IC50 & Target VHL體外研究E3 ligase Ligand-Linker Conjugates 7 Free Base, extracted from patent US20170008904A1, can be used in1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEthe synthesis of compound A1895 in example 3 1.REFERENCES1. Crew, Andrew P, et al. MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE.US20170008904A1.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5370