Dorzolamide-hydrochloride-L671152-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDorzolamide hydrochlorideCat. No.: HY-B0109ACAS No.: 130693-82-2Synonyms: L671152 hydrochloride; MK507 hydrochloride分式: CHClNOS分量: 360.9作靶點: Carbonic Anhydrase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn so

2、lvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 14 mg/mL (38.79 mM; Need ultrasonic and warming)DMSO : 1 mg/mL (insoluble or slightly soluble)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.7709 mL 13.8543 mL 27.7085 mL5 mM 0.5542 mL 2.7709 mL 5.5417 mL10 mM 0.2771 mL 1.3854 mL 2.7709 mL請根據(jù)產(chǎn)品在不同

3、溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Dorzolamide (L671152; MK507) 鹽酸鹽碳酸酐酶（CA）抑制劑，可作于青光眼。REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Rankin AJ, et al. Effects of ocular administration of ophthalmic 2% dorzolamide hydrochloride solution on aqueous humor flow rat

4、e andintraocular pressure in clinically normal cats. Am J Vet Res. 2012 Jul;73(7):1074-8.2. Sarup V, et al. Dorzolamide and timolol saves retinal ganglion cells in glaucomatous adult rats. J Ocul Pharmacol Ther. 2005Dec;21(6):454-62.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021