Rimeporide-EMD-87580-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERimeporideCat. No.: HY-19273CAS No.: 187870-78-6Synonyms: EMD-87580分式: CHNOS分量: 333.38作靶點(diǎn): Sodium Channel作通路: Membrane Transporter/Ion Channel儲(chǔ)存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 20 mg/mL

2、(59.99 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9996 mL 14.9979 mL 29.9958 mL5 mM 0.5999 mL 2.9996 mL 5.9992 mL10 mM 0.3000 mL 1.4998 mL 2.9996 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)

3、的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.24 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.24 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSo

4、lubility: 2.08 mg/mL (6.24 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Rimeporide (EMD-87580)種有效的選擇性 Na+/H+ 交換泵 (NHE-1) 抑制劑。IC50 & Target NHE1 1體外研究 Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH andRimepor

5、ide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD).Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that itis mutation independent 1.REFERENCES1. F.Porte-Thom, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchennemuscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379