OSMI-4 - OGT 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOSMI-4Cat. No.: HY-114361CAS No.: 2260791-14-6分式: CHClNOS分量: 604.09作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 62.5 mg/mL (103.46 mM; Need ultrasonic)Mass Solvent1

2、 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.6554 mL 8.2769 mL 16.5538 mL5 mM 0.3311 mL 1.6554 mL 3.3108 mL10 mM 0.1655 mL 0.8277 mL 1.6554 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬?chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終

3、溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.44 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (3.44 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 OSMI-4種低納 爾的O-連接的N-酰半乳糖胺轉(zhuǎn)移酶 (OGT

4、) 的抑制劑，其在細(xì)胞中的EC50 值為3 M。IC50 & Target EC50: 3 M (OGT) 1.體外研究 OSMI-4 (4b) is the best OGT inhibitor reported to date, with a -3 M EC50 in cells, making it especiallyattractive for probing OGTs complex biology 1.REFERENCES1. Martin SES, et al. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct24;140(42):13542-13545.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa