Guaiacol-2-Methoxyphenol-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGuaiacolCat. No.: HY-N1380CAS No.: 90-05-1Synonyms: 2-Methoxyphenol分式: CHO分量: 124.14作靶點(diǎn): COX; NF-B作通路: Immunology/Inflammation; NF-B儲(chǔ)存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg

2、/mL (805.54 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 8.0554 mL 40.2771 mL 80.5542 mL5 mM 1.6111 mL 8.0554 mL 16.1108 mL10 mM 0.8055 mL 4.0277 mL 8.0554 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(

3、為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (20.14 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (20.14 mM); Clear solution1/2 Master of Small M

4、olecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (20.14 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Guaiacol種從愈創(chuàng)樹脂分離的酚類化合物，抑制 LPS 刺激的 COX-2 表達(dá)和 NF-B 激活 1。具有抗炎活性 1。IC50 & Target COX-2 NF-B體外研究 Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-B) activation

5、and cyclooxygenase (COX)-2gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such asPhenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, asindicated by their 50% inhibition concentrations, which decline in the follo

6、wing order: Phenol (1600 M) Vanillin (500 M) Guaiacol (72 M) Eugenol (12 M) 1.REFERENCES1. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated withlipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400