Polyoxyl-15-hydroxystearate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEPolyoxyl15hydroxystearateCat.No.:HY-136349CASNo.:70142-34-6作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:150mg/mL(Needultrasonic)H2O:<0.1mg/mL(insoluble)請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥3.75mg/mL(InfinitymM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:3.75mg/mL(InfinitymM);Suspendedsolution;Needultrasonic3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥3.75mg/mL(InfinitymM);ClearsolutionBIOLOGICALACTIVITY?物活性Polyoxyl15hydroxystearate?種?離?型?離?表活性劑和乳化劑。Polyoxyl15hydroxystearate?于改難溶性藥物的溶解度和溶出度。體外研究Polyoxyl15hydroxystearateisfoundtobeeffectiveinenhancingthesolubilityandstabilityofCurcumin(HY-N0005)[2].Polyoxyl15hydroxystearateisemployedasacarriertobuildupastableCoQ10-loadedmicelledeliverysystem[3].1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEREFERENCES[1].ChoHJ,etal.Poly(lactic-co-glycolic)Acid/SolutolHS15-BasedNanoparticlesforDocetaxelDelivery.JNanosciNanotechnol.2016;16(2):1433‐1436.[2].SeoSW,etal.PreparationandpharmacokineticevaluationofcurcuminsoliddispersionusingSolutol?HS15asacarrier.IntJPharm.2012;424(1-2):18‐25.[3].LiuL,etal.Kolliphor?HS15MicellesfortheDeliveryofCoenzymeQ10:Preparation,Characterization,andStability.AAPSPharmSciTech.2016;17(3):757-766.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379