腫瘤抗血管生成療法課件

第九章腫瘤抗血管生成療法Angiogenesis第九章腫瘤抗血管生成療法1詞彙介紹血管生成(Angiogenesis)Angeion:sselgenesis:formation·癌細胞轉(zhuǎn)移(Metastasis內(nèi)皮細胞(endothelialcel促血管生成以及抑制血管生成之因子(Anti-andpro-angiogenicfactor詞彙介紹2NormalangiogenesisNormalAngiogenesisinChildrenNormalAngiogenesisinAdultsNormalangiogenesis3正常胚胎血管新生(NormalangiogenesisinEmbryo〉胚胎發(fā)育過程中,需要大量的養(yǎng)分以及代謝,新生之血管生成才足以供應(yīng)快速發(fā)育之胚胎正常之生長所需正常胚胎血管新生4正常成體血管新生NormalangiogenesisinAdults)≯因為新生之組織需要大量的營養(yǎng)成分以及修補物質(zhì)’而免疫糸統(tǒng)的成員亦在此過程中扮演重要角色’而為新生之血管所運送至受傷的組織內(nèi)。正常成體血管新生5Historyofantiangiogenicdrugs1971:Thefieldbeganinearly1970swithJudahFolkman'shypothesisthattumorgrowthwouldbehaltedifitweredeprivedofabloodsupply1989:Dr.NapoleneFerraidentifiedandisolateVEGF1996:Dr.JefferyIsnerpublishedfirstclinicaltrialsregardingVEGF2004:FDAapprovesfirstantiangiogenicdrugtotreatcolorectalcancer(AvastinHistoryofantiangiogenicdrug6ArticleTalkWIKIPEDIAJudahFolkmanWildpedia,thefreeencyclopediastbestknownforhisresearchbywhichatumorattractsbloodvesselstonourishitselfandsustainitsaxistence.HefoundedthefieldofangiogenesisresearchwhichumberoftherapiesbasedoninhibitingorstimulatingneoascularizationRandomartdenEarly2WarkenangiogenesisAboutwkpedlaReferencessExtemallinksRacanchangEsContactWikipediaEarlylifecouldoffercuresinadditiontocomfort.Hisfatherreplied,Inthatcase,youcanbearabbi-likedoctor."wordshissontooktoheatily''spaniedhisfather,arabbi,onvisitstohospitalpatientsTLanguagesFolkmangraduatedfromTheOhioStateUniversityin1953,andthenHarvardMedicalSchoolain1957.WhilestillastudentatHarvardMaduation.hedidhissurgicalresidencyatMassachusettsGeneralHospital,whereherosetotherankofChiefResidentinSurgery.DuDeutschetween1960and1962.FolkmanservedintheUnitedStatesNawasalieutenant.wherehestudiedbloodvesselgrowthattheNationalEspanolany,Folkmaninventedanimplantabledevicefortimeddrugrelease4anddonateditpatent-freetotheWarldPopulationCouncil.ItcorK。nLetzebuergeschIn1971.hereportedintheNewEnglandJoumalofMedicmethatallI0r5areangiogenesis-dependent.ifatumorcouldbestopporsk(bokmal>haughhishypothesiswasinitiallydisregardedbymostexpertsinthefieldpersistedwithhisresearchPortuguesAftermorethanadecade.histheorybecamewidelyacceptedandisnowbeingexploitedinthetreatmentofagrowingnumberofdiseaseArticleTalk7obusttumorgrowthrequiresthepresenceofalocalvascularnetworlthatsuppliesbothoxygenandnutrientstotumorcellsAngiogenesisanti-angiogenic6k2)actorsTheAngiogenicBalanceobusttumorgrowthrequiresth8contents血管生成與腫瘤(1)血管生成的一般過程(2)腫瘤血管生成(3)腫瘤血管生成與腫瘤的發(fā)生、生長和轉(zhuǎn)移·二、腫瘤血管生成的評估三、血管生成抑制劑研究及臨床應(yīng)用現(xiàn)狀·四、抗血管生成治療與提高放射治療敏感性·五、抗血管生成藥物臨床試驗存在的一些問題contents9第一節(jié)、血管生成與腫瘤(1)血管生成的一般過程血管生成anglogenesIs)是指在機體生長發(fā)育過程中或創(chuàng)傷修復(fù)、缺血缺氧和炎癥等情況下,Angiogenesis原有微血管內(nèi)皮細胞(endothelialcell,EC)經(jīng)過生芽、遷移、增殖與基質(zhì)重塑等形成新毛細血管的過程。第一節(jié)、血管生成與腫瘤10腫瘤抗血管生成療法課件11腫瘤抗血管生成療法課件12腫瘤抗血管生成療法課件13腫瘤抗血管生成療法課件14腫瘤抗血管生成療法課件15腫瘤抗血管生成療法課件16腫瘤抗血管生成療法課件17腫瘤抗血管生成療法課件18腫瘤抗血管生成療法課件19腫瘤抗血管生成療法課件20腫瘤抗血管生成療法課件21腫瘤抗血管生成療法課件22腫瘤抗血管生成療法課件23腫瘤抗血管生成療法課件24腫瘤抗血管生成療法課件25腫瘤抗血管生成療法課件26腫瘤抗血管生成療法課件27腫瘤抗血管生成療法課件28腫瘤抗血管生成療法課件29腫瘤抗血管生成療法課件30腫瘤抗血管生成療法課件31腫瘤抗血管生成療法課件32腫瘤抗血管生成療法課件33腫瘤抗血管生成療法課件34腫瘤抗血管生成療法課件35腫瘤抗血管生成療法課件36腫瘤抗血管生成療法課件37腫瘤抗血管生成療法課件38腫瘤抗血管生成療法課件39腫瘤抗血管生成療法課件40腫瘤抗血管生成療法課件41腫瘤抗血管生成療法課件42腫瘤抗血管生成療法課件43腫瘤抗血管生成療法課件44腫瘤抗血管生成療法課件45腫瘤抗血管生成療法課件46腫瘤抗血管生成療法課件47腫瘤抗血管生成療法課件48腫瘤抗血管生成療法課件49腫瘤抗血管生成療法課件50腫瘤抗血管生成療法課件51腫瘤抗血管生成療法課件52腫瘤抗血管生成療法課件53腫瘤抗血管生成療法課件54腫瘤抗血管生成療法課件55腫瘤抗血管生成療法課件56腫瘤抗血管生成療法課件57腫瘤抗血管生成療法課件58腫瘤抗血管生成療法課件59腫瘤抗血管生成療法課件60腫瘤抗血管生成療法課件61腫瘤抗血管生成療法課件62腫瘤抗血管生成療法課件63腫瘤抗血管生成療法課件64腫瘤抗血管生成療法課件65腫瘤抗血管生成療法課件66腫瘤抗血管生成療法課件67腫瘤抗血管生成療法課件68腫瘤抗血管生成療法課件69腫瘤抗血管生成療法課件70腫瘤抗血管生成療法課件71腫瘤抗血管生成療法課件72腫瘤抗血管生成療法課件73腫瘤抗血管生成療法課件74腫瘤抗血管生成療法課件75腫瘤抗血管生成療法課件76腫瘤抗血管生成療法課件77腫瘤抗血管生成療法課件78腫瘤抗血管生成療法課件79腫瘤抗血管生成療法課件80腫瘤抗血管生成療法課件81腫瘤抗血管生成療法課件82第九章腫瘤抗血管生成療法Angiogenesis第九章腫瘤抗血管生成療法83詞彙介紹血管生成(Angiogenesis)Angeion:sselgenesis:formation·癌細胞轉(zhuǎn)移(Metastasis內(nèi)皮細胞(endothelialcel促血管生成以及抑制血管生成之因子(Anti-andpro-angiogenicfactor詞彙介紹84NormalangiogenesisNormalAngiogenesisinChildrenNormalAngiogenesisinAdultsNormalangiogenesis85正常胚胎血管新生(NormalangiogenesisinEmbryo〉胚胎發(fā)育過程中,需要大量的養(yǎng)分以及代謝,新生之血管生成才足以供應(yīng)快速發(fā)育之胚胎正常之生長所需正常胚胎血管新生86正常成體血管新生NormalangiogenesisinAdults)≯因為新生之組織需要大量的營養(yǎng)成分以及修補物質(zhì)’而免疫糸統(tǒng)的成員亦在此過程中扮演重要角色’而為新生之血管所運送至受傷的組織內(nèi)。正常成體血管新生87Historyofantiangiogenicdrugs1971:Thefieldbeganinearly1970swithJudahFolkman'shypothesisthattumorgrowthwouldbehaltedifitweredeprivedofabloodsupply1989:Dr.NapoleneFerraidentifiedandisolateVEGF1996:Dr.JefferyIsnerpublishedfirstclinicaltrialsregardingVEGF2004:FDAapprovesfirstantiangiogenicdrugtotreatcolorectalcancer(AvastinHistoryofantiangiogenicdrug88ArticleTalkWIKIPEDIAJudahFolkmanWildpedia,thefreeencyclopediastbestknownforhisresearchbywhichatumorattractsbloodvesselstonourishitselfandsustainitsaxistence.HefoundedthefieldofangiogenesisresearchwhichumberoftherapiesbasedoninhibitingorstimulatingneoascularizationRandomartdenEarly2WarkenangiogenesisAboutwkpedlaReferencessExtemallinksRacanchangEsContactWikipediaEarlylifecouldoffercuresinadditiontocomfort.Hisfatherreplied,Inthatcase,youcanbearabbi-likedoctor."wordshissontooktoheatily''spaniedhisfather,arabbi,onvisitstohospitalpatientsTLanguagesFolkmangraduatedfromTheOhioStateUniversityin1953,andthenHarvardMedicalSchoolain1957.WhilestillastudentatHarvardMaduation.hedidhissurgicalresidencyatMassachusettsGeneralHospital,whereherosetotherankofChiefResidentinSurgery.DuDeutschetween1960and1962.FolkmanservedintheUnitedStatesNawasalieutenant.wherehestudiedbloodvesselgrowthattheNationalEspanolany,Folkmaninventedanimplantabledevicefortimeddrugrelease4anddonateditpatent-freetotheWarldPopulationCouncil.ItcorK。nLetzebuergeschIn1971.hereportedintheNewEnglandJoumalofMedicmethatallI0r5areangiogenesis-dependent.ifatumorcouldbestopporsk(bokmal>haughhishypothesiswasinitiallydisregardedbymostexpertsinthefieldpersistedwithhisresearchPortuguesAftermorethanadecade.histheorybecamewidelyacceptedandisnowbeingexploitedinthetreatmentofagrowingnumberofdiseaseArticleTalk89obusttumorgrowthrequiresthepresenceofalocalvascularnetworlthatsuppliesbothoxygenandnutrientstotumorcellsAngiogenesisanti-angiogenic6k2)actorsTheAngiogenicBalanceobusttumorgrowthrequiresth90contents血管生成與腫瘤(1)血管生成的一般過程(2)腫瘤血管生成(3)腫瘤血管生成與腫瘤的發(fā)生、生長和轉(zhuǎn)移·二、腫瘤血管生成的評估三、血管生成抑制劑研究及臨床應(yīng)用現(xiàn)狀·四、抗血管生成治療與提高放射治療敏感性·五、抗血管生成藥物臨床試驗存在的一些問題contents91第一節(jié)、血管生成與腫瘤(1)血管生成的一般過程血管生成anglogenesIs)是指在機體生長發(fā)育過程中或創(chuàng)傷修復(fù)、缺血缺氧和炎癥等情況下,Angiogenesis原有微血管內(nèi)皮細胞(endothelialcell,EC)經(jīng)過生芽、遷移、增殖與基質(zhì)重塑等形成新毛細血管的過程。第一節(jié)、血管生成與腫瘤92腫瘤抗血管生成療法課件93腫瘤抗血管生成療法課件94腫瘤抗血管生成療法課件95腫瘤抗血管生成療法課件96腫瘤抗血管生成療法課件97腫瘤抗血管生成療法課件98腫瘤抗血管生成療法課件99腫瘤抗血管生成療法課件100腫瘤抗血管生成療法課件101腫瘤抗血管生成療法課件102腫瘤抗血管生成療法課件103腫瘤抗血管生成療法課件104腫瘤抗血管生成療法課件105腫瘤抗血管生成療法課件106腫瘤抗血管生成療法課件107腫瘤抗血管生成療法課件108腫瘤抗血管生成療法課件109腫瘤抗血管生成療法課件110腫瘤抗血管生成療法課件111腫瘤抗血管