R-S-Ivosidenib-R-S-AG-120-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(R,S)-IvosidenibCat.No.:HY-18767ACASNo.:2070009-31-1Synonyms:(R,S)-AG-120分?式:C??H??ClF?N?O?分?量:582.96作?靶點(diǎn):IsocitrateDehydrogenase(IDH)作?通路:MetabolicEnzyme/Protease儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:3.33mg/mL(5.71mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.7154mL8.5769mL17.1538mL5mM0.3431mL1.7154mL3.4308mL10mM---------請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥0.33mg/mL(0.57mM);ClearsolutionBIOLOGICALACTIVITY?物活性(R,S)-Ivosidenib((R,S)-AG-120)Ivosidenib(AG-120)的對映體，活性較低。戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?CellRep.2022Feb15;38(7):110391.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].Popovici-MullerJ,etal.DiscoveryofAG-120(Ivosidenib):AFirst-in-ClassMutantIDH1InhibitorfortheTreatmentofIDH1MutantCancers.ACSMedChemLett.2018Jan19;9(4):300-305.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax