IRAK4-IN-7-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEIRAK4-IN-7Cat.No.:HY-109585CASNo.:1801343-74-7分?式:C??H??N?O?分?量:417.42作?靶點(diǎn):IRAK作?通路:Immunology/Inflammation儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:13.89mg/mL(33.28mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3957mL11.9783mL23.9567mL5mM0.4791mL2.3957mL4.7913mL10mM0.2396mL1.1978mL2.3957mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.39mg/mL(3.33mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性IRAK4-IN-7?種選擇性，有效且具有?服活性的?介素1受體相關(guān)激酶4(IRAK4)抑制劑，于專利?獻(xiàn)WO2015104688A1(例1)。IRAK4-IN-7可?于癌癥以及炎癥疾病的相關(guān)研究。IC50&TargetIRAK4(IC50)體內(nèi)研究IRAK4-IN-7hasanti-cancerandanti-inflammatoryactivities,itcanbeusedforcancerandinflammatorydiseasestreatment[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?EmergMicrobesInfect.2021Jul20;104867.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].VenkateshwarRaoGUMMADI,etal.Bicyclicheterocyclylderivativesasirak4inhibitors.WO2015104688A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>