PROTAC-AR-Degrader-4-TFA-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPROTACARDegrader-4TFACat.No.:HY-111848A分?式:C??H??F?N?O??分?量:884.03作?靶點:SNIPERs;PROTACs;AndrogenReceptor作?通路:PROTAC;Others儲存?式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實驗DMSO:200mg/mL(226.24mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.1312mL5.6559mL11.3118mL5mM0.2262mL1.1312mL2.2624mL10mM0.1131mL0.5656mL1.1312mL請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5mg/mL(5.66mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:5mg/mL(5.66mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性PROTACARDegrader-4包含IAP配體結合團，linker和雄激素受體(AR)配體結合團。于cIAP1的降解劑也被稱為SNIPER[1]。IC50&TargetcIAP1體外研究SpecificandNongeneticIAPs-dependentProteinErasers(SNIPERs)arebifunctionalcompoundswhicharedesignedbyconjugatinganIAPs-recognitionstructurewithatargetprotein-recognitionstructure.Targetingproteinsfordegradationinvolvesthreesteps.1,itstworecognitionstructuresallowSNIPERtoformacomplexlinkingIAPs,whichhaveE3ligaseactivity,withthetargetprotein.2,thetargetproteinispolyubiquitinatedbyIAPs.3,thepolyubiquitinatedproteinisdegradedbyproteasome.REFERENCES[1].ItohY,etal.Design,synthesisandbiologicalevaluationofnuclearreceptor-degradationinducers.BioorgMedChem.2011Nov15;19(22):6768-78.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400