PI3K-VEGFR2-IN-1-DataSheet-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPI3K/VEGFR2-IN-1Cat.No.:HY-151635分?式:C??H??ClN?OS分?量:343.83作?靶點:PI3K;VEGFR;Apoptosis作?通路:PI3K/Akt/mTOR;ProteinTyrosineKinase/RTK;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性PI3K/VEGFR2-IN-1?種有效的雙重PI3K/VEGFR2抑制劑，抑制PI3K和VEGFR2的IC50值分別為2.21和68μM。PI3K/VEGFR2-IN-1誘導細胞凋亡(apoptosis)。PI3K/VEGFR2-IN-1可?于癌癥的研究。IC50&TargetPI3KVEGFR22.21μM(IC50)68μM(IC50)體外研究PI3K/VEGFR2-IN-1(compound8;1.56-100μM;24h;HePG2,MCF-7,Hela,andPC3cells)inhibitscellproliferativeinadose-dependentmanner[1].PI3K/VEGFR2-IN-1(10mg/mL;24h;MCF-7andHelacells)arrestscellcycleatG1/Sphaseandinducesapoptosis[1].CellViabilityAssay[1]CellLine:HePG2,MCF-7,Hela,andPC3cellsConcentration:1.56-100μMIncubationTime:24hoursResult:HadantitumoractivitywithIC50valuesof7.94,9.73?,11.58,and17.49μMforHela,HePG2,MCF-7andPC3cells,respectively.CellCycleAnalysis[1]CellLine:MCF-7cells1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEConcentration:10mg/mLIncubationTime:24hoursResult:ArrestedcellcycleinG1/Sphaseat24hby51.23%.CellCycleAnalysis[1]CellLine:MCF-7andHelacellsConcentration:10mg/mLIncubationTime:24hoursResult:Enhancedlateapoptoticinductionwith14.11%atHelacells.REFERENCES[1].El-KhoulyOA,et,al.Design,synthesisandcomputationalstudyofnewbenzofuranhybridsasdualPI3K/VEGFR2inhibitorstargetingcancer.SciRep.2022Oct12;12(1):17104.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58