Tosufloxacin-A-61827-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETosufloxacinCat.No.:HY-B1802CASNo.:100490-36-6Synonyms:A-61827分?式:C??H??F?N?O?分?量:404.34作?靶點(diǎn):Antibiotic;Bacterial作?通路:Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Tosufloxacin(A-61827)?種具有?服活性的氟喹諾酮類抗?素。Tosufloxacin對?蘭?陽性和?蘭?性細(xì)表現(xiàn)出?泛的抗活性。IC50&TargetQuinolone體外研究Tosufloxacintosylatehydrate(T-3262)(0.05-3.13μg/mL;18h)showsantibacterialactivitiesagainstS.aureus,Staphylococcusepidermidis,streptococci,enterococci,Bacteroidesfragilis,Clostridiumdifficile,andClostridiumperfringens[2].CellViabilityAssay[2]CellLine:S.aureus,Staphylococcusepidermidis,streptococci,enterococci,Bacteroidesfragilis,Clostridiumdifficile,andClostridiumperfringensConcentration:0.05-3.13μg/mLIncubationTime:18hoursResult:ShowedMIC90s(MICsfor90%oftheisolatestested)rangingfrom0.05to1.56μg/mLforS.aureus,Staphylococcusepidermidis,streptococci,andenterococci.ShowedMIC90sof1.56,3.13,and0.20μg/mLforBacteroidesfragilis,Clostridiumdifficile,andClostridiumperfringens,respectively.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體內(nèi)研究Tosufloxacintosylatehydrate(T-3262)(oralgavage;0.16-13.39mg/kg;once)treatmentshowsantibacterialactivityagainstS.aureus,E.coli,andP.aeruginosainvivo[2].AnimalModel:MaleSlc:ICRmiceinfectedwithS.aureus[2]Dosage:1.27-2.15mg/kgAdministration:Oralgavage;1.27-2.15mg/kg;onceResult:Showed50%effectivedose(ED50)of1.62mg/kg(bodyweight)at7daysafterinfection.ShowedMICvalueof0.0125μg/mL.AnimalModel:MaleSlc:ICRmiceinfectedwithE.coli[2]Dosage:0.16-0.30mg/kgAdministration:Oralgavage;0.16-0.30mg/kg;onceResult:Showed50%effectivedose(ED50)of0.22mg/kg(bodyweight)at7daysafterinfection.ShowedMICvalueof0.0125μg/mL.AnimalModel:MaleSlc:ICRmiceinfectedwithP.aeruginosa[2]Dosage:7.66-13.39mg/kgAdministration:Oralgavage;7.66-13.39mg/kg;onceResult:Showed50%effectivedose(ED50)of10.13mg/kg(bodyweight)at7daysafterinfection.ShowedMICvalueof0.78μg/mL.戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?PLoSNeglTropDis.2019Aug20;13(8):e0007681.?CurrMicrobiol.2021Dec14;79(1):12.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ChuDT,etal.SynthesisandbiologicalpropertiesofA-71497:aprodrugoftosufloxacin.DrugsExpClinRes.1990;16(9):435-43.[2].FujimakiK,etal.InvitroandinvivoantibacterialactivitiesofT-3262,anewfluoroquinolone.AntimicrobAgentsChemother.1988Jun;32(6):827-33.McePdfHeight2/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapp