Suvratoxumab-MEDI4893-DataSheet-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESuvratoxumabCat.No.:HY-P99583CASNo.:1629620-18-3Synonyms:MEDI4893作?靶點:Bacterial作?通路:Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Suvratoxumab(MEDI4893)?種長效且具有親和??的?化抗α-毒素單克隆抗體(IgG1κ型)。Suvratoxumab能有效中和α-毒素(?種關鍵的??葡萄球毒?因?)。Suvratoxumab可提?免疫功能低下的??肺炎模型的存活率并減少肺損傷。Suvratoxumab還可增強Vancomycin(HY-B0671)或Linezolid(HY-10394)的抗活性。IC50&Targetα-toxinofS.aureus[1][2][3].體內研究Suvratoxumab(5,15,45mg/kg;i.p.;single)increasessurvivalratesinanimmunocompromisedmurinepneumoniamodel[1].Suvratoxumab(15mg/kg;i.p.;single)prophylaxisreducespulmonarydamageandincreasesmacrophagephagocytosisinmice[1].Suvratoxumab(15mg/kg;i.p.;single)prophylaxisimprovestheeffectivenessofantibiotic(vancomycinorlinezolid)treatmentinmice[1].AnimalModel:Specific-pathogen-free,7-to9-week-old,femaleC57BL/6Jmice(immunocompromisedpneumoniamodel)[1].Dosage:5,15,45mg/kgAdministration:Intraperitonealinjection;singleResult:Resultedindose-dependentincreasesinsurvivalratesandreductionsinbacterialCFU.AnimalModel:Specific-pathogen-free,7-to9-week-old,femaleC57BL/6Jmice(immunocompromised1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEpneumoniamodel)[1].Dosage:15mg/kgAdministration:Intraperitonealinjection;singleResult:ProphylaxisprotectedthelungsofS.aureus-infectedimmunocompromisedmicefromαtoxin-mediateddamage.REFERENCES[1].HuaL,etal.MEDI4893*PromotesSurvivalandExtendstheAntibioticTreatmentWindowinaStaphylococcusaureusImmunocompromisedPneumoniaModel.AntimicrobAgentsChemother.2015Aug;59(8):4526-32.[2].YuXQ,etal.Safety,Tolerability,andPharmacokineticsofMEDI4893,anInvestigational,Extended-Half-Life,Anti-StaphylococcusaureusAlpha-ToxinHumanMonoclonalAntibody,inHealthyAdults.AntimicrobAgentsChemother.2016Dec27;61(1):e01020-16.[3].OganesyanV,etal.Mechanismsofneutralizationofahumananti-α-toxinantibody.JBiolChem.2014Oct24;289(43):29874-80.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon