醫(yī)學(xué)免疫學(xué)教學(xué)課件：MHC complement_第1頁(yè)
醫(yī)學(xué)免疫學(xué)教學(xué)課件：MHC complement_第2頁(yè)
醫(yī)學(xué)免疫學(xué)教學(xué)課件：MHC complement_第3頁(yè)
醫(yī)學(xué)免疫學(xué)教學(xué)課件：MHC complement_第4頁(yè)
醫(yī)學(xué)免疫學(xué)教學(xué)課件：MHC complement_第5頁(yè)
已閱讀5頁(yè)，還剩43頁(yè)未讀， 繼續(xù)免費(fèi)閱讀

下載本文檔

版權(quán)說(shuō)明：本文檔由用戶(hù)提供并上傳，收益歸屬內(nèi)容提供方，若內(nèi)容存在侵權(quán)，請(qǐng)進(jìn)行舉報(bào)或認(rèn)領(lǐng)

文檔簡(jiǎn)介

TheMHCComplementMHC

MajorHistocompatibility

ComplexHuman:HLAMouse:H-2T-cellsrecogniseantigenthatis:a)Processedintopeptides

then:b)PresentedbyMHC MHC

2mainversions:

MHCclassIfoundonallnucleatedcellsinthebody

MHCclassIIfoundon‘professionalantigen-presentingcells’(APC):Dendriticcells,macrophages,B-cells

(alsoonthymicepitheliumandactivatedhumanT-cells)

MHCclassIspecializedforalertingcytotoxicT-cellstointracellularinfection

MHCclassIIspecializedforactivatinghelperT-cellsHumanMHCClassI:HLA-A,-B,-CHumanMHCClassII:HLA-DP,-DQ,-DRMouseMHCClassI:H-2K,H-2D,H-2LMouseMHCClassII:I-A,I-EMHCClassIIIdoesnotencodeantigen-presentingmolecules,butdoesencodethecomplementcomponentsC2,C4&FactorB,thecytokinesTNFandlymphotoxin,etcThehumanandmouseMHCgenelociPolymorphicHLAspecificitiesandtheirinheritanceStructureofMHCmoleculesStructureofMHCmoleculesPeptidebindsintoMHCpeptide-bindinggroovePeptidebindsintoMHCpeptide-bindinggrooveMHCH-2KbSecondaryanchorMainanchorMainanchorKochC.P.etal.(2013)ScrutinizingMHC-IBindingPeptidesandTheirLimitsofVariation.PLoSComputBiol9(6):e1003088.Y=TyrosineF=PhenylalanineL=LeucineM=MethionineI=IsoleucineV=ValineMajoranchorresiduesdeterminepeptidebindingtoMHCClassIpresentspeptidestoCD8+

cytotoxicTcellsClassIIpresentspeptidestoCD4+helperTcellsAntigenpresentationbyMHCTheimportanceofMHCintransplantationHost-versus-graftreactionsFirstcadaverickidneygraftsurvivalRecognitionofgraftantigensbyalloreactiveT-cellsMHCisageneticfactorinautoimmunediseaseMHCisageneticfactorinautoimmunediseaseSummaryMHCpresentsprocessedantigentotheTCRonT-cellsMHCgenesarethemostpolymorphicgenesinthehumangenomeInhumanMHCclassIisHLA-A,-B,-CandMHCclassIIisHLA-DP,-DQ,-DRMHCisthestrongestgeneticdeterminantoftransplant rejection(particularlyHLA-A,-Band-DR)ParticularMHCvariantsareassociatedwithautoimmunediseasesTheMHCComplementPeterJDelvesp.delves@ucl.ac.ukComplementAsetof~20ormoredifferentproteinsActinanenzymicamplificationcascadeUponactivationthecomplementsystemgeneratesanumberofactivecomponentsinvolvedinseveralaspectsoftheimmuneresponseincludingacuteinflammationAcuteinflammationThetissueresponsetoinjuryorinfectionCharacterisedbyincreasedbloodflowandentryofleukocytesintothetissuesResultsin:swellingrednesselevatedtemperaturepainThreewaystoactivatecomplement:ClassicalpathwayLectinpathwayAlternativepathwayComplementactivationpathwaysComplementactivationpathwaysComplementactivationpathwaysComplementactivationpathwaysComplementactivationpathwaysComplementactivationpathwaysComplementactivationpathwaysComplementactivationpathwaysComplementactivationpathwaysC3convertasecleavesC3intoC3a+C3bSplittingofC3isakeyeventincomplementactivationO.K.,butwhatdoescomplementactuallydo?ComplementcomponentsinvolvedinimmuneresponsesComplementcomponentsinvolvedinimmuneresponsesComplementcomponentsinvolvedinimmuneresponsesComplementcomponentsinvolvedinimmuneresponsesComplementcomponentsinvolvedinimmuneresponsesActivitiesgeneratedbythetriggeringofthecomplementcascadeComplementregulatoryproteinsOpsonisationLysis-themembraneattackcomplexFormationofthemembraneattackcomplex(C5b-9)C3a,C4aandC5aactivatemastcellsE-selectinCD15

SummaryInflammationrapidlyrecruitsneutrophilstothesiteoftheinfectionComplementplaysakeyroleinthisprocessbycausingmastcelldegranulat

溫馨提示

  • 1. 本站所有資源如無(wú)特殊說(shuō)明，都需要本地電腦安裝OFFICE2007和PDF閱讀器。圖紙軟件為CAD,CAXA,PROE,UG,SolidWorks等.壓縮文件請(qǐng)下載最新的WinRAR軟件解壓。
  • 2. 本站的文檔不包含任何第三方提供的附件圖紙等，如果需要附件，請(qǐng)聯(lián)系上傳者。文件的所有權(quán)益歸上傳用戶(hù)所有。
  • 3. 本站RAR壓縮包中若帶圖紙，網(wǎng)頁(yè)內(nèi)容里面會(huì)有圖紙預(yù)覽，若沒(méi)有圖紙預(yù)覽就沒(méi)有圖紙。
  • 4. 未經(jīng)權(quán)益所有人同意不得將文件中的內(nèi)容挪作商業(yè)或盈利用途。
  • 5. 人人文庫(kù)網(wǎng)僅提供信息存儲(chǔ)空間，僅對(duì)用戶(hù)上傳內(nèi)容的表現(xiàn)方式做保護(hù)處理，對(duì)用戶(hù)上傳分享的文檔內(nèi)容本身不做任何修改或編輯，并不能對(duì)任何下載內(nèi)容負(fù)責(zé)。
  • 6. 下載文件中如有侵權(quán)或不適當(dāng)內(nèi)容，請(qǐng)與我們聯(lián)系，我們立即糾正。
  • 7. 本站不保證下載資源的準(zhǔn)確性、安全性和完整性, 同時(shí)也不承擔(dān)用戶(hù)因使用這些下載資源對(duì)自己和他人造成任何形式的傷害或損失。

最新文檔

評(píng)論

0/150

提交評(píng)論