INF-195-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEINF195Cat.No.:HY-164304CASNo.:1211379-56-4分?式:C??H??ClNO?分?量:323.81作?靶點(diǎn):Pyroptosis作?通路:Apoptosis;Immunology/Inflammation儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:200mg/mL(617.65mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.0882mL15.4412mL30.8823mL5mM0.6176mL3.0882mL6.1765mL10mM0.3088mL1.5441mL3.0882mLBIOLOGICALACTIVITY?物活性INF195?種NLRP3抑制劑。INF195可以抑制NLRP3驅(qū)動(dòng)的巨噬細(xì)胞焦亡和IL-1β釋放，EC50值為0.15μM。INF195在低劑量下可以減?離體???臟的梗死積，有效預(yù)防?肌缺?/再灌注損傷。體外研究INF195(0.1-100μM,72h)caninhibitNLRP3drivenmacrophagepyroptosisandIL-1βrelease[1].INF195(5-10μM,10min)canreducetheinfarctsizeofisolatedmouseheartsatlowdoses,effectivelypreventingmyocardialischemia/reperfusioninjury[1].CellCytotoxicityAssay[1].CellLine:Humanmacrophages1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEConcentration:0.1–100μMIncubationTime:72hResult:Inhibitedpyroptosisbyabout40%,withanEC50of0.15μM.REFERENCES[1].GastaldiS,etal.NovelNLRP3inhibitorINF195:Lowdosesprovideeffectiveprotectionagainstmyocardialischemia/reperfusioninjury.VasculPharmacol.2024Jun17;156:107397.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02