Laduviglusib-Standard-CHIR-99021-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELaduviglusib(Standard)Cat.No.:HY-10182RCASNo.:252917-06-9Synonyms:CHIR-99021(Standard);CT99021(Standard)分?式:C??H??Cl?N?分?量:465.34作?靶點:Organoid;GSK-3;Autophagy;Wnt;β-catenin作?通路:StemCell/Wnt;PI3K/Akt/mTOR;Autophagy儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Laduviglusib(Standard)Laduviglusib的標(biāo)準(zhǔn)品。Laduviglusib(CHIR-99021)?種有效的，選擇性的，具有?服活性的GSK-3α/β抑制劑，IC50為10nM和6.7nM。Laduviglusib對GSK-3的選擇性?CDC2，ERK2和其他蛋?激酶?500倍以上。Laduviglusib還?種有效的Wnt/β-catenin信號通路激活劑。CHIR-99021可增強??和?類胚胎?細胞的?我更新。Laduviglusib能誘導(dǎo)細胞?噬(autophagy)。REFERENCES[1].RingDB,etal.Selectiveglycogensynthasekinase3inhibitorspotentiateactivationofglucosetransportandutilizationinvitroandinvivo.Diabetes.2003Mar;52(3):588-95.[2].YeS,etal.Pleiotropyofglycogensynthasekinase-3inhibitionbyCHIR99021promotesself-renewalofembryonicstemcellsfromrefractorymousestrains.PLoSOne.2012;7(4):e35892.[3].BennettCN,etal.RegulationofWntsignalingduringadipogenesis.JBiolChem.2002Aug23;277(34):30998-1004.[4].NaujokO,etal.CytotoxicityandactivationoftheWnt/beta-cateninpathwayinmouseembryonicstemcellstreatedwithfourGSK3inhibitors.BMCResNotes.2014Apr29;7:273.[5].WangX,etal.Pharmacologicallyblockingp53-dependentapoptosisprotectsintestinalstemcellsandmicefromradiation.SciRep.2015Apr10;5:8566.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559