Nisoldipine-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENisoldipine(Standard)Cat.No.:HY-17402RCASNo.:63675-72-9分?式:C??H??N?O?分?量:388.41作?靶點(diǎn):CalciumChannel;ReactiveOxygenSpecies作?通路:MembraneTransporter/IonChannel;NeuronalSignaling;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Nisoldipine(Standard)Nisoldipine的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Nisoldipine(BAY-k5552;Sular)?效特異的L型Cav1.2通道阻斷劑，IC50為10nM。REFERENCES[1].HamiltonSF,HouleLM,ThadaniU.Rapid-releaseandcoat-coreformulationsofnisoldipineintreatmentofhypertension,angina,andheartfailure.HeartDis.1999Nov-Dec;1(5):279-88.[2].FodorJG.NisoldipineCC:efficacyandtolerabilityinhypertensionandischemicheartdisease.CardiovascDrugsTher.1997Jan;10Suppl3:873-9.[3].D.J.Duncker,J.M.Hartog,P.G.Hugenholtz,etal.Theeffectsofnisoldipine(BayK5552)oncardiovascularperformanceandregionalbloodflowinpentobarbital-anaesthetizedpigswithorwithoutβ-adrenoceptorblockade.BritishJournalofPharmacology.1986,88(1):9-18[4].JanW.DeJong,TomHuizer,JanG.P.Tijssen.Energyconservationbynisoldipineinischaemicheart.BritishJournalofPharmacology.1984,83(4):943-949McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02