Solasonine-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemESolasonine(Standard)Cat.No.:HY-N0070RCASNo.:19121-58-5分子式:C??H??NO??分子量:884.06作用靶點(diǎn):Ferroptosis;Ferroptosis;GlutathionePeroxidase;GlutathionePeroxidase;ReactiveOxygenSpecies;ReactiveOxygenSpecies作用通路:Apoptosis;MetabolicEnzyme/Protease;Immunology/Inflammation;NF-κB儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Solasonine(Standard)是Solasonine的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Solasonine是一種可從茄屬植物中提取的鐵死亡(ferroptosis)誘導(dǎo)劑，具有抗感染、抗癌、促進(jìn)神經(jīng)發(fā)生等作用。Solasonine通過抑制GPX4來誘導(dǎo)谷胱甘肽氧化還原系統(tǒng)的破壞，促進(jìn)肝癌細(xì)胞鐵死亡，可用于癌癥研究[1][2]。REFERENCESDingX,etal.Purification,antitumoractivityinvitroofsteroidalglycoalkaloidsfromblacknightshade(SolanumnigrumL.).FoodChem.2013Nov15;141(2):1181-6.JinM,etal.Solasoninepromotesferroptosisofhepatomacarcinomacellsviaglutathioneperoxidase4-induceddestructionoftheglutathioneredoxsystem.BiomedPharmacother.2020Sep;129:110282.DingX,etal.Purification,antitumoractivityinvitroofsteroidalglycoalkaloidsfromblacknightshade(SolanumnigrumL.).FoodChem.2013Nov15;141(2):1181-6.JinM,etal.Solasoninepromotesferroptosisofhepatomacarcinomacellsviaglutathioneperoxidase4-induceddestructionoftheglutathioneredoxsystem.BiomedPharmacother.2020Sep;129:110282.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: