Sotalol-hydrochloride-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemESotalol(hydrochloride)(Standard)Cat.No.:HY-B0437RCASNo.:959-24-0分子式:C??H??ClN?O?S分子量:308.82作用靶點:AdrenergicReceptor;PotassiumChannel作用通路:GPCR/GProtein;NeuronalSignaling;MembraneTransporter/IonChannel儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Sotalol(hydrochloride)(Standard)是Sotalol(hydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Sotalolhydrochloride(MJ1999)是一種口服有效，非選擇性β-腎上腺素受體阻斷劑。Sotalolhydrochloride具有抗心律失常作用，可用于小兒心律失常的研究。Sotalolhydrochloride阻斷β受體和鉀KCNH2通道，具有抗抗癲癇作用[1]IC50&Targetβ-adrenergicreceptor[1];Potassiumchannels[1]REFERENCESMartaReyes-Corral,etal.DifferentialFreeIntracellularCalciumReleasebyClassIIAntiarrhythmicsinCancerCellLines.JPharmacolExpTher.2019Apr;369(1):152-162.XiaomeiLi,etal.PediatricDosingofIntravenousSotalolBasedonBodySurfaceAreainPatientswithArrhythmia.PediatrCardiol.2017Oct;38(7):1450-1455.KingaKBorowicz-Reutt,etal.Sotaloldoesnotinterferewiththeantielectroshockactionofselectedsecond-generationantiepilepticdrugsinmice.PharmacolRep.2021Apr;73(2):516-524.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-537