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1、BIOCHEMISTRYTEACHING PLAN(Bilingual Teaching)(2011-12)CHAPTER 20 AMINO ACID DEGRADATION AND SYNTHESIS1. OBJECTIVE AND REQUIREMENTAfter learning this chapter, students should have a good mastery of1. overview.2. ketogenic amino acids, glucogenic and ketogenic amino acids.3. one carbon units and role

2、of folic acid.4. biosynthesis of alanine, aspartate, glutamate, asparagine and glutamine.After learning this chapter, students should have a fair knowledge of1. catabolism of the carbon skeletons of amino acids to form seven intermediate products.2. phenylketonuria, maple syrup urine disease, albini

3、sm,homocystinuria and alkaptonuria.2. MAJOR TEACHING CONTENTS (50 min×4)1. glucogenic amino acids and ketogenic amino acids.2. amino acids that form oxaloacetate, -ketoglutarate, pyruvate.3. concept of one carbon unit role of folic acid.4. biosynthesis of nonessential amino acids: alanine, glut

4、amic acid, aspartic acid, tyrosine, etc.5. metabolic defects in amino acid metabolism.3. IMPROTANT POINTS1. glucogenic amino acids and ketogenic amino acids.2. amino acids that form oxaloacetate, -ketoglutarate, pyruvate.3. concepts of essential amino acids and one carbon unit.4. biosynthesis of non

5、essential amino acids: alanine, glutamic acid, aspartic acid, tyrosine, etc.5. metabolic defects in amino acid metabolism.4. DIFFICULT POINTS mechanisms of sulfanilamide as an antibiotic and methotrexate as an antineoplastic agent.5. TEACHING TECHNIQUES1. heuristic approach, question-and-answer meth

6、od.2. laying stress on key points and difficult points.3. homework assignment.6. TEACHING INSTRUMENTALITIES1. Multimedia systems.2. CAI courseware.7. TEACHER李文凱8. STUDENTSthe Grade 2012 International Students 9. CLASSROOMConference Room, International Student Building, Xiangya School of Medicine10.

7、TEXTBOOKRichard A. Harvey, Denis Ferrier. (2011) Lippincotts Illustrated Reviews: Biochemistry, 5th ed. Baltimore:Lippincott Williams & Wilkins11. REFERENCES1. David L. Nelson, Michael M. Cox.(2008) Lehninger Principles of Biochemistry, 4th ed. New York: W. H. Freeman and Company2. 查錫良.生物化學(xué).第七版.

8、北京:人民衛(wèi)生出版社,20083. 王鏡巖,朱圣庚,徐長法.生物化學(xué).第三版.北京:高等教育出版社,200212. LECTURE NOTESCHAPTER 20 AMINO ACID DEGRADATION AND SYNTHESISI. OverviewII. Glucogenic and ketogenic amino acidsA. Glucogenic amino acidsB. Ketogenic amino acidsIII. Catabolism of the carbon skeletons of amino acidsA. Amino acids that form oxa

9、loacetateB. Amino acids that form -ketoglutarateC. Amino acids that form pyruvateD. Amino acids that form fumarateE. Amino acids that form succinyl CoA: methionineF. Other amino acids that form succinyl CoAG. Amino acids that form acetyl CoA or acetoacetyl CoAH. Catabolism of the branched-chain amino acidsIV. Role of folic acid in amino acid metabolismA. Folic acid: a carrier of one-carbon unitsV. Biosynthesis of nonessential amino acidsA. Synthesis from keto acidsB. Synthesis by amidationC. ProlineD. Serine, glycine, and cysteineE. Tyrosine

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