Virus-Protease-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/virus-protease.html Virus HYPERLINK https:/www.MedChemE/Targets/virus-protease.html HYPERLINK https:/www.MedChemE/Targets/virus-protease.html ProteaseViral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases ca

2、talyze thecleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalyticmechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition ofthese sequence patterns

3、 by a complementary substrate binding site of the enzyme ensures a high degree of specific recognitionand cleavage.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019(COVID-19). Initial spike protein priming by transmembrane

4、protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. Aftera SARS-CoV-2 virion attaches to a target cell, the cells protease TMPRSS2 cuts open the spike protein of the virus, exposing afusion peptide.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/virus-protease.html Virus HYPERLIN

5、K https:/www.MedChemE/Targets/virus-protease.html HYPERLINK https:/www.MedChemE/Targets/virus-protease.html Protease HYPERLINK https:/www.MedChemE/Targets/virus-protease.html HYPERLINK https:/www.MedChemE/Targets/virus-protease.html Inhibitors HYPERLINK https:/www.MedChemE/plus-jnj-a07.html (+)-JNJ-

6、A07Cat. No.: HY-139602 HYPERLINK https:/www.MedChemE/_-_-Epicatechin-gallate.html (-)-Epicatechin HYPERLINK https:/www.MedChemE/_-_-Epicatechin-gallate.html HYPERLINK https:/www.MedChemE/_-_-Epicatechin-gallate.html gallate(Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate) Cat. No.: HY-N0002(+)

7、-JNJ-A07 is a highly potent, orally activepan-serotype dengue virus inhibitor targeting theNS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolarto picomolar activity against a panel of 21clinical isolates.(-)-Epicatechin gallate (Epicatechin gallate)inhibits cyclooxygenase-1 (COX-1) with an IC of507.5

8、M.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.57%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/alpha-pinene.html (-)-PineneCat. No.: HY-N0549 HYPERLINK https:/www.MedChemE

9、/e-3-4-dimethoxycinnamic-acid.html (E)-3,4-Dimethoxycinnamic HYPERLINK https:/www.MedChemE/e-3-4-dimethoxycinnamic-acid.html HYPERLINK https:/www.MedChemE/e-3-4-dimethoxycinnamic-acid.html acid(E)-O-Methylferulic acid) Cat. No.: HY-N1778A(-)-Pinene is a monoterpene and shows sleepenhancing property

10、through a direct binding toGABAA-benzodiazepine (BZD) receptors by acting asa partial modulator at the BZD binding site.(E)-3,4-Dimethoxycinnamic acid is the less activeisomer of 3,4-Dimethoxycinnamic acid.3,4-Dimethoxycinnamic acid exerts anti-apoptoticeffects on L-02 cells via the ROS-mediatedsign

11、aling pathway. Anti-apoptotic effects.Purity: 99.63%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg, 1 g, 5 gPurity: 99.90%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mg HYPERLINK https:/www.MedChemE/2-hydroxy-4-methylbenzenesulphonic-acid-ammonium.html 2-Hydroxy-4-met

12、hylbenzenesulphonic HYPERLINK https:/www.MedChemE/2-hydroxy-4-methylbenzenesulphonic-acid-ammonium.html HYPERLINK https:/www.MedChemE/2-hydroxy-4-methylbenzenesulphonic-acid-ammonium.html acid HYPERLINK https:/www.MedChemE/2-hydroxy-4-methylbenzenesulphonic-acid-ammonium.html HYPERLINK https:/www.Me

13、dChemE/2-hydroxy-4-methylbenzenesulphonic-acid-ammonium.html ammoniumCat. No.: HY-136574 HYPERLINK https:/www.MedChemE/2-Phenylethanol.html 2-Phenylethanol(Phenylethyl alcohol; Phenethyl alcohol; Benzyl carbinol) Cat. No.: HY-B12902-Hydroxy-4-methylbenzenesulphonic acid ammoniumis an impurity of Pol

14、icresulen. Policresulen is apotent NS2B/NS3 protease inhibitor with an IC of500.48 g/mL. Policresulen effectively inhibits thereplication of DENV2 virus in BHK-21 cells with anIC of 4.99 g/mL.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2-Phenylethanol (Phenethyl alcohol), extr

15、actedfrom rose, carnation, hyacinth, Aleppo pine,orange blossom and other organisms, is acolourless liquid. It has a pleasant floral odorand also an autoantibiotic produced by the fungusCandida albicans.Purity: 99.64%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mg, 1 g HYPERLINK https

16、:/www.MedChemE/O-Methylferulic_acid.html 3,4-Dimethoxycinnamic HYPERLINK https:/www.MedChemE/O-Methylferulic_acid.html HYPERLINK https:/www.MedChemE/O-Methylferulic_acid.html acid HYPERLINK https:/www.MedChemE/O-Methylferulic_acid.html HYPERLINK https:/www.MedChemE/4-hydroxy-2-methylbenzenesulfonic-

17、acid-ammonium.html 4-Hydroxy-2-methylbenzenesulfonic HYPERLINK https:/www.MedChemE/4-hydroxy-2-methylbenzenesulfonic-acid-ammonium.html HYPERLINK https:/www.MedChemE/4-hydroxy-2-methylbenzenesulfonic-acid-ammonium.html acid HYPERLINK https:/www.MedChemE/4-hydroxy-2-methylbenzenesulfonic-acid-ammoniu

18、m.html HYPERLINK https:/www.MedChemE/4-hydroxy-2-methylbenzenesulfonic-acid-ammonium.html ammonium(O-Methylferulic acid) Cat. No.: HY-N1778Cat. No.: HY-1365753,4-Dimethoxycinnamic acid (O-Methylferulic acid)is a monomer extracted and purified from Securidacainappendiculata Hassk. 3,4-Dimethoxycinnam

19、ic acidexerts anti-apoptotic effects on L-02 cells viathe ROS-mediated signaling pathway. Anti-apoptoticeffects.Purity: 99.54%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg4-Hydroxy-2-methylbenzenesulfonic acid ammonium isan impurity of Policresulen. Policresulen is apotent NS2B/NS3

20、protease inhibitor with an IC of500.48 g/mL. Policresulen effectively inhibits thereplication of DENV2 virus in BHK-21 cells with anIC of 4.99 g/mL.50Purity: 98%Clinical Data: No Development ReportedSize: 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Benzenebutyric_acid.html 4-Phenylbutyric HYPERLINK

21、https:/www.MedChemE/Benzenebutyric_acid.html HYPERLINK https:/www.MedChemE/Benzenebutyric_acid.html acid HYPERLINK https:/www.MedChemE/Benzenebutyric_acid.html HYPERLINK https:/www.MedChemE/4-phenylbutyric-acid-d11.html 4-Phenylbutyric HYPERLINK https:/www.MedChemE/4-phenylbutyric-acid-d11.html HYPE

22、RLINK https:/www.MedChemE/4-phenylbutyric-acid-d11.html acid-d11(4-PBA; Benzenebutyric acid) Cat. No.: HY-A0281 (4-PBA-d11; Benzenebutyric acid-d11) Cat. No.: HY-A0281S4-Phenylbutyric acid (4-PBA) is an inhibitor ofHDAC and endoplasmic reticulum (ER) stress, usedin cancer and infection research.4-Ph

23、enylbutyric acid-d11 (4-PBA-d11) is thedeuterium labeled 4-Phenylbutyric acid.4-Phenylbutyric acid (4-PBA) is an inhibitor ofHDAC and endoplasmic reticulum (ER) stress, usedin cancer and infection research.Purity: 99.98%Clinical Data: LaunchedSize: 500 mgPurity: 98%Clinical Data: No Development Repo

24、rtedSize: 10 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/4E2RCat.html 4E2RCat HYPERLINK https:/www.MedChemE/4E2RCat.html HYPERLINK https:/www.MedChemE/5-hydroxytoluene-2-4-disulphonic-acid-diammonium.html 5-Hydroxytoluene-2,4-disulphonic HYPERLI

25、NK https:/www.MedChemE/5-hydroxytoluene-2-4-disulphonic-acid-diammonium.html HYPERLINK https:/www.MedChemE/5-hydroxytoluene-2-4-disulphonic-acid-diammonium.html acid HYPERLINK https:/www.MedChemE/5-hydroxytoluene-2-4-disulphonic-acid-diammonium.html HYPERLINK https:/www.MedChemE/5-hydroxytoluene-2-4

26、-disulphonic-acid-diammonium.html diammoniumCat. No.: HY-100733 Cat. No.: HY-1365734E2RCat is an inhibitor of eIF4E-eIF4G interactionwith an IC of 13.5 M.50Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg5-Hydroxytoluene-2,4-disulphonic acid diamm

27、oniumis an impurity of Policresulen. Policresulen is apotent NS2B/NS3 protease inhibitor with an IC of500.48 g/mL. Policresulen effectively inhibits thereplication of DENV2 virus in BHK-21 cells with anIC of 4.99 g/mL.50Purity: 98%Clinical Data: No Development ReportedSize: 50 mg, 100 mg HYPERLINK h

28、ttps:/www.MedChemE/a2ti-1.html A2ti-1 HYPERLINK https:/www.MedChemE/a2ti-1.html HYPERLINK https:/www.MedChemE/a2ti-2.html A2ti-2Cat. No.: HY-136465 Cat. No.: HY-136466A2ti-1 is a selective and high-affinity annexinA2/S100A10 heterotetramer (A2t) inhibitor with anIC of 24 M. A2ti-1 specifically disru

29、pts the50protein-protein interaction (PPI) between A2 andS100A10. A2ti-1 prevents human papillomavirus type16 (HPV16) infection.A2ti-2 is a selective and low-affinity annexinA2/S100A10 heterotetramer (A2t) inhibitor with anIC of 230 M. A2ti-2 specifically disrupts the50protein-protein interaction (P

30、PI) between A2 andS100A10. A2ti-2 prevents human papillomavirus type16 (HPV16) infection.Purity: 99.83%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.85%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK h

31、ttps:/www.MedChemE/alpha-Mangostin.html alpha-Mangostin(-Mangostin) Cat. No.: HY-N0328 HYPERLINK https:/www.MedChemE/Aminothiazole.html Aminothiazole(2-Aminothiazole; 2-Thiazolylamine) Cat. No.: HY-12396alpha-Mangostin (-Mangostin) is a dietaryxanthone with broad biological activities, such asantiox

32、idant, anti-allergic, antiviral,antibacterial, anti-inflammatory and anticancereffects. It is an inhibitor of mutant IDH1(IDH1-R132H) with a K of 2.85 M.iPurity: 99.64%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 25 mg, 50 mg, 100 mgAminothiazole (2-Aminothiazole), a typicalheteroc

33、yclic amine, is a precursor for thesynthesis of biologically active moleculesincluding sulfur agents, biocides, fungicides,antibiotics, dyes and chemical reactionaccelerators.Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mg, 5 g, 10 g HYPERLINK https:/www.MedChemE/Angelici

34、n.html Angelicin HYPERLINK https:/www.MedChemE/Angelicin.html HYPERLINK https:/www.MedChemE/anthraquinone.html Anthraquinone(Isopsoralen) Cat. No.: HY-N0763Cat. No.: HY-N0354Angelicin, a furocoumarin naturally occurringtricyclic aromatic compound, structurally relatedto psoralens, is reported to hav

35、e anti-cancer,antiviral, anti-inflammatory activity.Anthraquinone is used as a precursor for dyeformation.Purity: 99.86%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 98.14%Clinical Data: No Development ReportedSize: 100 mg HYPERLINK https:/www.MedChemE/Artesunate.

36、html Artesunate HYPERLINK https:/www.MedChemE/Artesunate.html HYPERLINK https:/www.MedChemE/artesunate-d3.html Artesunate-d3Cat. No.: HY-N0193 Cat. No.: HY-N0193SArtesunate is an inhibitor of both STAT-3 andexported protein 1 (EXP1).Artesunate-d3 is the deuterium labeled Artesunate.Artesunate is an

37、inhibitor of both STAT-3 andexported protein 1 (EXP1).Purity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 10 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/artesunate-d4.html Artesunate-d4Cat. No.: HY-N0193S1 HYPERLINK https:/www.

38、MedChemE/aspirin.html Aspirin(Acetylsalicylic Acid; ASA) Cat. No.: HY-14654Artesunate-d4 is deuterium labeled Artesunate.Artesunate is an inhibitor of both STAT-3 andexported protein 1 (EXP1).Aspirin is a non-selective and irreversibleinhibitor of COX-1 and COX-2 with IC s of 5 and50210 g/mL.Purity:

39、 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.92%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g, 5 g HYPERLINK https:/www.MedChemE/aspirin-d3.html Aspirin-d3(Acetylsalicylic Acid-d3; ASA-d3) Cat. No.: HY-14654S HYPERLINK https:/www.MedChemE/aspirin-d4.html Aspirin-d4(Ace

40、tylsalicylic Acid-d4; ASA-d4) Cat. No.: HY-14654S1Aspirin-d3 (Acetylsalicylic Acid-d3) is thedeuterium labeled Aspirin. Aspirin is anon-selective and irreversible inhibitor of COX-1and COX-2 with IC s of 5 and 210 g/mL.50Aspirin-d4 (Acetylsalicylic Acid-d4) is thedeuterium labeled Aspirin. Aspirin i

41、s anon-selective and irreversible inhibitor of COX-1and COX-2 with IC s of 5 and 210 g/mL.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98.85%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/AZ960.html AZ960Cat. No.: HY-10411 HY

42、PERLINK https:/www.MedChemE/Bergenin.html Bergenin(Cuscutin) Cat. No.: HY-N0017AZ960 is a potent and specific inhibitor of theJAK2 kinase with a K of 0.45 nM.iBergenin is a cytoprotective and antioxidativepolyphenol found in many medicinal plants.Bergenin has a wide spectrum activities such ashepato

43、protective, antiinflammatory,immunomodulatory, antitumor, antiviral, andantifungal properties.Purity: 97.15%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.63%Clinical Data: LaunchedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 50 mg HYPERLINK https:/www.Med

44、ChemE/Brequinar.html Brequinar HYPERLINK https:/www.MedChemE/Brequinar.html HYPERLINK https:/www.MedChemE/carmofur.html Carmofur(DUP785; NSC 368390) Cat. No.: HY-108325 (HCFU) Cat. No.: HY-B0182Brequinar (DUP785) is a potent inhibitor ofdihydroorotate dehydrogenase (DHODH) with an ICof 5.2 nM for hu

45、man DHODH. Brequinar haspotent activities against a broad spectrum ofviruses. Brequinar also has an anti-SARS2 activity.50Carmofur (HCFU), a derivative of 5-Fluorouracil,is an antineoplastic agent. Carmofur is aninhibitor of acid ceramidase with an IC of 7950nM for the rat enzyme. Carmofur inhibits

46、theSARS-CoV-2 main protease (Mpro).Purity: 99.75%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mgPurity: 99.95%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 500 mg HYPERLINK https:/www.MedChemE/ccf0058981.html CCF0058981 HYPERLINK https:/www.MedChemE/ccf0058981.html HYPERLINK https:/www.MedChe

47、mE/Danthron.html Danthron(CCF981) Cat. No.: HY-132306 (Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone) Cat. No.: HY-B0923CCF0058981 (CCF981), 3-chlorophenyl analogue, is anoncovalent SARS-CoV-2 3CLpro (SC2) inhibitorwith an IC50 of 68 nM. CCF0058981 inhibits SC1(SARS-CoV-1 3CLpro) with an IC of 19 n

48、M.50CCF0058981 has antiviral efficacy and has thepotential for COVID-19 research.Danthron is a natural product extracted from thetraditional Chinese medicine rhubarb. Danthronfunctions in regulating glucose and lipidmetabolism by activating AMPK.Purity: 98.35%Clinical Data: No Development ReportedSi

49、ze: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.70%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/danthron-d6.html Danthron-d6(Dantron-d6; Chrysazin-d6; 1,8-Dihydroxyanthraquinone-d6) Cat. No.: HY-B0923S HYPERLI

50、NK https:/www.MedChemE/dipotassium-glycyrrhizinate.html Dipotassium HYPERLINK https:/www.MedChemE/dipotassium-glycyrrhizinate.html HYPERLINK https:/www.MedChemE/dipotassium-glycyrrhizinate.html glycyrrhizinate(Glycyrrhizic acid dipotassium; Dipotassium glycyrrhizate) Cat. No.: HY-N0184ADanthron-d6 (

51、Dantron-d6) is the deuterium labeledDanthron. Danthron is a natural product extractedfrom the traditional Chinese medicine rhubarb.Danthron functions in regulating glucose and lipidmetabolism by activating AMPK.Dipotassium glycyrrhizinate is a natural compound,inhibits atopic dermatitis-related gene

52、 expressionwith anti-anti-inflammatory activity.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mgPurity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 20 mg HYPERLINK https:/www.MedChemE/Dynasore.html DynasoreCat. No.: HY-15304 HYPERLINK https:/www.MedChemE/Ebselen.html

53、 Ebselen(SPI-1005; PZ-51; CCG-39161) Cat. No.: HY-13750Dynasore is a cell-permeable dynamin inhibitorwith an IC of 15 M.50Ebselen (SPI-1005), a glutathione peroxidasemimetic, is a potent voltage-dependent calciumchannel (VDCC) blocker. Ebselen potently inhibitsMpro (IC =0.67 M) and virus50 COVID-19(

54、EC =4.67 M).Ebselen is an inhibitor of50 HIV-1capsid CTD dimerization.Purity: 98.70%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mgPurity: 99.58%Clinical Data: Phase 3Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/encephalitic-alphavirus-in-1.html Enc

55、ephalitic HYPERLINK https:/www.MedChemE/encephalitic-alphavirus-in-1.html HYPERLINK https:/www.MedChemE/encephalitic-alphavirus-in-1.html alphavirus-IN-1Cat. No.: HY-145842 HYPERLINK https:/www.MedChemE/ensitrelvir.html Ensitrelvir(S-217622) Cat. No.: HY-143216Encephalitic alphavirus-IN-1 has antivi

56、ralactivity for VEEV and EEEV with EC s of 0.2450M and 0.16 M, respectively. Encephaliticalphavirus-IN-1 has robust mouse plasma stability,and no obvious cytotoxicity.Ensitrelvir (S-217622) is the first orally activenon-covalent, non-peptidic, SARS-CoV-2 3CLprotease inhibitor (IC =13 nM).50Purity: 9

57、8%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.48%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/ensitrelvir-fumarate.html Ensitrelvir HYPERLINK https:/www.MedChemE/ensitrelvir-fumarate.html HYPERLINK https:/www.MedChem

58、E/ensitrelvir-fumarate.html fumarate HYPERLINK https:/www.MedChemE/ensitrelvir-fumarate.html HYPERLINK https:/www.MedChemE/ESI-09.html ESI-09(S-217622 fumarate) Cat. No.: HY-143216ACat. No.: HY-16704Ensitrelvir (S-217622) fumarate is the firstorally active non-covalent, non-peptidic,SARS-CoV-2 3CL p

59、rotease inhibitor (IC =13 nM).50ESI-09 is a novel noncyclic nucleotide EPACantagonist with IC values of 3.2 and 1.4 M for50EPAC1 and EPAC2, respectively.Purity: 99.44%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.75%Clinical Data: No Development ReportedSize

60、: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/foscarnet-sodium.html Foscarnet HYPERLINK https:/www.MedChemE/foscarnet-sodium.html HYPERLINK https:/www.MedChemE/foscarnet-sodium.html sodium HYPERLINK https:/www.MedChemE/foscarnet-sodium.html (Trisodium phosphonoformate; Phosp