Medetomidine-hydrochloride-MPV785-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMedetomidine hydrochlorideCat. No.: HY-17034BCAS No.: 86347-15-1Synonyms: MPV785分式: CHClN分量: 236.74作靶點(diǎn): Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 m

2、onth溶解性數(shù)據(jù)體外實(shí)驗(yàn) : 50 mg/mL (211.20 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.2240 mL 21.1202 mL 42.2404 mL5 mM 0.8448 mL 4.2240 mL 8.4481 mL10 mM 0.4224 mL 2.1120 mL 4.2240 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Medeto

3、midine hydrochloride是2腎上腺素受體激動劑，對2和1腎上腺素受體的Ki分別為1.08 nM和1750 nM。REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylatedCREB in mouse amygdala. Neuropsychopharmac

4、ology, 2004. 29(2): p. 229-39.2. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur JPharmacol, 2004. 497(2): p. 161-71.3. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstrictionin humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F