Namodenoson-CF-102-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENamodenosonCat. No.: HY-12365CAS No.: 163042-96-4Synonyms: CF-102; 2-Cl-IB-MECA分式: CHClINO分量: 544.73作靶點: Adenosine Receptor作通路: GPCR/G Protein儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO :

2、 31 mg/mL (56.91 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.8358 mL 9.1789 mL 18.3577 mL5 mM 0.3672 mL 1.8358 mL 3.6715 mL10 mM 0.1836 mL 0.9179 mL 1.8358 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Namodenoson (CF-102)個選擇

3、性的 A3 adenosine 受體的激動劑，選擇性分別是A1，A2的2500到1400倍。IC50 & Target Ki:0.33 nM (A3 adenosine receptor) 1 2.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE體外研究 In human ADF cells of astroglial lineage, 100 nM Namodenoson (2-Cl-IB-MECA) caused a markedreorganization of the cytoskeleton, with appearance of s

4、tress fibres and numerous cell protrusions. Highconcentrations of Namodenoson (2-Cl-IB-MECA) directly cause influx of Ca2+ 2.體內研究 Intravenous administration of 200 g/kg Namodenoson (2-Cl-IB-MECA) resulted in a short-lastinghypotension, which was accompanied by a 50-100-fold increase in plasma histam

5、ine concentrations.Administration of a second dose of Namodenoson (2-Cl-IB-MECA) did not elicit any hemodynamic effects 1.REFERENCES1. Van Schaick EA et al. Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats. Eur J Pharmacol. 1996 Jul 25;308(3):311-4.2. Jacobson KA et al. Adenosine A3 receptors: novel ligands and paradoxical effects. Trends Pharmacol Sci. 1998 May;19(5):184-91.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3