CP21R7-CP21-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECP21R7Cat. No.: HY-100207CAS No.: 125314-13-8Synonyms: CP21分式: CHNO分量: 317.34作靶點: GSK-3作通路: PI3K/Akt/mTOR; Stem Cell/Wnt儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 32 mg/mL (100.84 mM)*

2、 means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.1512 mL 15.7560 mL 31.5119 mL5 mM 0.6302 mL 3.1512 mL 6.3024 mL10 mM 0.3151 mL 1.5756 mL 3.1512 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗

3、的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.88 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 CP21R7種有效的 GSK-3 抑制劑，IC50 值為 1.8 nM；CP21R7 同時可抑制 PKC，IC50 值為 19

4、00nM。IC50 & Target GSK-3 PKC1.8 nM (IC50) 1900 nM (IC50)體外研究 CP21R7 (Compound 9) is a selective inhibitor of GSK-3, with an IC50 of 1.8 nM; the IC50 of CP21R7against PKC is 1900 nM 1. CP21R7 (CP21, 3 M) potently activates canonical Wnt signaling with highestactivity. CP21 significantly increases tot

5、al levels of intracellular -catenin. CP21 combined with BMP4induces commitment of hPSCs towards mesoderm 2.REFERENCES1. Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6.2. Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015Aug;17(8):994-1003.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792