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1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERU 24969Cat. No.: HY-16688CAS No.: 66611-26-5分式: CHNO分量: 228.29作靶點: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 30 mg/mL (131.41 mM)*

2、 means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.3804 mL 21.9020 mL 43.8039 mL5 mM 0.8761 mL 4.3804 mL 8.7608 mL10 mM 0.4380 mL 2.1902 mL 4.3804 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 RU 24969是5-HT1A 和 5-HT1B 受體的選擇性激動劑。IC50 & T

3、arget 5-HT1A, 5-HT1B 1體內(nèi)研究RU 24969 (0.03-3.0 mg/kg; s.c.; 15 minutes) dose-dependently decreases water consumption in waterdeprived rats 3.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEAnimal Model: Male Sprague-Dawley rats (water bottles were removed for 23.75 hours) 3Dosage: 0.03, 0.3, 1, 3 mg/

4、kgAdministration: Subcutaneous injection; 15 minutesResult: Dose-dependently decreased water consumption.REFERENCES1. Doods HN, et al. Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlationbetween 5-HT1A affinity and hypotensive activity.

5、Eur J Pharmacol. 1985 Jun 19;112(3):363-70.2. Green AR, et al. The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour oftreatment with antidepressants. Neuropharmacology. 1984 Jun;23(6):655-61.3. Aronsen D, et al. RU 24969-produced adipsia

6、and hyperlocomotion: Differential role of 5HT1A and 5HT1B receptor mechanisms.Pharmacol Biochem Behav. 2014 May 15;124C:1-4.4. Cheetham SC, et al. Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1Breceptor. Br J Pharmacol. 1993 Dec;110(4):1621-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40

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