器官移植的發(fā)展與未來(lái)課件

1、器官移植的發(fā)展與未來(lái)2022/7/27器官移植的發(fā)展與未來(lái)Human chimera, or “ homo novo. ” Mans original structure has been modified so that he can accept an organ “ from elsewhere ”器官移植的發(fā)展與未來(lái)Myth and Legend器官移植的發(fā)展與未來(lái)Myth and Legend器官移植的發(fā)展與未來(lái)Myth and Legend器官移植的發(fā)展與未來(lái)Myth and LegendProf. V.Demikhov and his two-headed dog. photo

2、taken two days after the operation U.S.S.R (1950)器官移植的發(fā)展與未來(lái)MAIN STEPS IN GRAFT HISTORYTHE PLANT GRAFT: VERY EARLY IN MANS HISTORYTHE ANIMAL GRAFT: 18TH CENTRURYTHE HUMAN GRAFT: 18TH CENTURYORGAN TRANSPLANTATION: 20TH CENTURY器官移植的發(fā)展與未來(lái)FROM GARDEN TO FARMYARD器官移植的發(fā)展與未來(lái)FROM GARDEN TO FARMYARD器官移植的發(fā)展與未來(lái)

3、19TH CENTURY: ALL FROMS OF GRAFTSBoronios sheep (1804). Successful replacement skin grafts on the back of an ewe.器官移植的發(fā)展與未來(lái)Paul Bert next to Claude Bernard, performing a vivisection procedure in his laboratory at the College of France in 1889.器官移植的發(fā)展與未來(lái)Free split-skin graft on a burn of the shoulder

4、 and arm.器官移植的發(fā)展與未來(lái)THE KIDNEY: A PILOT ORGAN器官移植的發(fā)展與未來(lái)THE FIRST TRANSPLANTATION IN ANIMAL At the Vienna Medical Society meeting held in January 1902, the surgeon Emerich Ullmann reported the first case of renal transplantation performed in the neck of a dog. The ureter, brought out to the skin , ooz

5、ed a “ liquid which resemble urine” over a period of five days.器官移植的發(fā)展與未來(lái)Dr. Alexis Carrel A magician器官移植的發(fā)展與未來(lái)First renal transplantations in man : 1906-1913In 1906, Mathieu Jaboulay performed renal transplantation in man.He transplanted the left kidney of a pig, killed 3 hours previously, into the

6、 left elbow of a woman suffering from nephrotic syndrome.The graft removed on the third day and the vessels were found to be obstructed by clots.器官移植的發(fā)展與未來(lái)First transplantation between humans : 1933In 1933, the russian surgeon Voronoy (1896-1961) performed the first homologous renal transplantation

7、in man using a human cadaver kidney.器官移植的發(fā)展與未來(lái)Serge Voronoff, at the Collge de France. Testicular transplantation from a monkey to man. A retired indian army colonel in fine form after the operation.器官移植的發(fā)展與未來(lái)The Brigham commando : 1947A young woman was in profound coma with anuria for 10 days follo

8、wing an abortion complicated by acute tubulopathy due to septic shock and incompatible transfusion.David M. Hume (1917-1973)器官移植的發(fā)展與未來(lái)Paris, Christmas 1952 : the present from a mother to her sonMrs Renard and her son Marius to whom she donated a kidney in December 1952.Pelvic implantation of the kid

9、ney with restoration of the urinary tract.器官移植的發(fā)展與未來(lái)A real Success : 1954John Merrill and Joseph Murry (Nobel Prize 1991) at the Brigham in 1953First susccessful transplantation between two identical twins in 1954 by the Murry, Merrill and Harrison team.器官移植的發(fā)展與未來(lái)Peter Brian Medawar, Nobel Prize in

10、1960.Rejection was by the action of lymphocytes which described as “ immunocomeptent cells “器官移植的發(fā)展與未來(lái)MAJOR HISTOCOMPATIBILITY COMPLEX : 1952( Jean Dausset, Nobel Prize in 1980 )( Human MHC )器官移植的發(fā)展與未來(lái)Immunosuppression : Total Body Irradiation“Sam” and “Honest John”器官移植的發(fā)展與未來(lái)First prolonged survival

11、 of renal transplantation with an unrelated donorMrs Gen and her donor at Foch Hospital in 1960器官移植的發(fā)展與未來(lái)Development of Immunosuppressive DrugsMarianne Mattlaer with “Mana”, who received a kidney in 1960 with immunosuppression by azathioprine, with a litter tow years after the transplantation.器官移植的發(fā)

12、展與未來(lái)Advent of CyclosporineThe primitive fungus from which cyclosporine is extracted (Tolypocladium inflatum)Sir Roy Calne器官移植的發(fā)展與未來(lái)Progress in Hemodialysis William J. Kolff, father of the artificial kidney and heart. The first artificial kidney designed by Kolff in 1945.器官移植的發(fā)展與未來(lái)Tissue Typing“The c

13、entre effect”: Terasaki and statistics器官移植的發(fā)展與未來(lái)Organ PreservationFalkert O. Belzer. The first human kidney preserved on a perfusion machine prior to transplantation in August 1967.器官移植的發(fā)展與未來(lái)Organ Preservation器官移植的發(fā)展與未來(lái)Liver TransplantationThomas Starzl in the operating room on March 1, 1963, perfor

14、med the first liver transplantation, the recipient survived five hours after the transplantation.器官移植的發(fā)展與未來(lái)Oil painting by Sir Roy Calne (1990) represent a phase of liver transplantation coordinated by the entire surgical team.器官移植的發(fā)展與未來(lái)Pancreas and Intestinal TransplantationRichard Lillehei器官移植的發(fā)展與

15、未來(lái)Heart and Lung TransplantationDenise Darvall, the first human heart”donor” Louis Washkansky, the heart recipient. December 3, 1967.Christiaan N. Barnard, cardiovascular surgeon at Capetown.器官移植的發(fā)展與未來(lái)Artificial Heart器官移植的發(fā)展與未來(lái)Heart and Lung TransplantationJames D. Hardys team, performed the first h

16、uman lung transplantation on June 11, 1963, seven and a half months before they performed the first human heterologus heart transplantation.器官移植的發(fā)展與未來(lái)XenotransplantationThe first blood transfusion from animals to man were attempted in 1628.器官移植的發(fā)展與未來(lái)Xenotransplantation器官移植的發(fā)展與未來(lái)器官移植在臺(tái)灣的發(fā)展腎臟 1968.05.

17、27 臺(tái)大 李俊仁自體骨髓 1983.11.09 臺(tái)大 陳耀昌異體骨髓 1984.03.09 臺(tái)大 陳耀昌肝臟 1984.03.22 長(zhǎng)庚 陳肇隆胰臟 1984.04.01 長(zhǎng)庚 陳肇隆心臟 1987.07.17 臺(tái)大 朱樹勳肺臟 1991.07.10 北榮 王良順器官移植的發(fā)展與未來(lái)臺(tái)灣器官移植之父器官移植的發(fā)展與未來(lái)臺(tái)灣肺臟移植的先驅(qū)王良順教授，臺(tái)北榮總呼吸加護(hù)病房主任器官移植的發(fā)展與未來(lái)How the transplantation is doing?器官移植的發(fā)展與未來(lái)How the transplantation is doing?器官移植的發(fā)展與未來(lái)SPKTFrom Donor t

18、o Recipient From 8 AM to 2 AM 09/20/2003器官移植的發(fā)展與未來(lái)Liver and Pancreas in Back Table器官移植的發(fā)展與未來(lái)Y-graft ReconstructionSMASAEIAIIACIA器官移植的發(fā)展與未來(lái)Pancreas TransplantationCold/Warm Ischemic Time = 452 min/38 minPVDuodenum graftY-graft a.Pancreas graft器官移植的發(fā)展與未來(lái)Duodeno-jejunostomy in SPKTPancreas器官移植的發(fā)展與未來(lái)SPKT on 09/19/2003Pancreatico-Duodenal graftKidney graftJejunum器官移植的發(fā)展與未來(lái)First 24 hours Blood Sugar after SPKT器官移植的發(fā)展與未來(lái)First Month Blood Sugar after SPKT器官移植的發(fā)展與未來(lái)Renal Function after SPKT器官移植的發(fā)展與未來(lái)SPKT Happy Discharge on