Taurodeoxychloic-Acid-sodium-hydrate-Sodium-taurodeoxycholate-monohydrate-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETaurodeoxychloic Acid sodium hydrateCat. No.: HY-B1899ACAS No.: 110026-03-4Synonyms: Sodium taurodeoxycholate monohydrate分式: CHNNaOS+分量: 540.71作靶點(diǎn): Apoptosis; Caspase作通路: Apoptosis儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80

2、C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (231.18 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.8494 mL 9.2471 mL 18.4942 mL5 mM 0.3699 mL 1.8494 mL 3.6988 mL10 mM 0.1849 mL 0.9247 mL 1.8494 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄?/p>

3、請(qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.85 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (3.85 mM); Clear solution3

4、. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (3.85 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Taurodeoxychloic Acid (sodium hydrate) 通過(guò)阻斷鈣介導(dǎo)的凋亡通路和 Caspase-12的活化來(lái)阻細(xì)胞凋亡。Taurodeoxychloic Acid (sodium hydrate) 被于多種研究，如原發(fā)性膽汁性肝硬化 (PBC)，胰島素抵抗，淀粉樣變

5、性，囊性纖維化，膽汁淤積和肌萎縮側(cè)索硬化癥。IC50 & Target Caspase-12體內(nèi)研究 Taurodeoxychloic Acid (TUDCA) is neuroprotective in a transgenic animal model of Huntingtons disease 2.REFERENCES1. Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002Sep;

6、36(3):592-601.2. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntingtons disease. ProcNatl Acad Sci U S A. 2002 Aug 6;99(16):10671-6.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820