Cefoxitin-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECefoxitinCat. No.: HY-B1825CAS No.: 35607-66-0分式: CHNOS分量: 427.45作靶點(diǎn): Antibiotic; Bacterial作通路: Anti-infection儲存式: 4C, sealed storage, away from moisture and light* In solvent : -80C, 6 months; -20C, 1 month (sealedstorage, away

2、 from moisture and light)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (233.95 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3395 mL 11.6973 mL 23.3945 mL5 mM 0.4679 mL 2.3395 mL 4.6789 mL10 mM 0.2339 mL 1.1697 mL 2.3395 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ce

3、foxitin種譜的、具有抗活性的第代頭孢素。Cefoxitin 對蘭陽性/蘭性需氧和厭氧 1 2。體外研究 Cefoxitin has good activity against gram-positive bacteria. The MICs for several gram-positive pathogens arein the range of 1-6 g/mL 1.Cefoxitin has shown high efficacy killing B. burgdorferi at concentration of 1.25 M/mL 3.體內(nèi)研究Cefoxitin (20 mg/

4、kg; i.p.; daily; for 5 days) effectively kills B. burgdorferi in vivo C3H/HeN mouse model 3.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEAnimal Model: Four-week-old female C3H/HeN mice 3Dosage: 20 mg/kgAdministration: Intraperitoneal injection, daily, for five consecutive daysResult: Had shown h

5、igh efficacy killing B. burgdorferi in vivo. J Antimicrob Chemother. 2020 Mar 10. pii: dkaa053.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. E O Stapley, et al. Cefoxitin and cephamycins: microbiological studies. Rev Infect Dis. Jan-Feb 1979;1(1):73-89.2. R N Brogden, et al.

6、Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979Jan;17(1):1-37.3. Venkata Raveendra Pothineni, et al. In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. Drug Des DevelTher. 2018; 12: 29152921.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40