Chlorprothixene-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEChlorprothixenehydrochlorideCat.No.:HY-B0274ACASNo.:6469-93-8分?式:C??H??Cl?NS分?量:352.32作?靶點:DopamineReceptor;HistamineReceptor;Bacterial作?通路:GPCR/GProtein;NeuronalSignaling;Immunology/Inflammation;Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:2.5mg/mL(7.10mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.8383mL14.1916mL28.3833mL5mM0.5677mL2.8383mL5.6767mL10mM---------請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性Chlorprothixenehydrochloride?種多巴胺(dopamine)和組胺(histamine)受體拮抗劑，?親和?地結(jié)合?D1，D2，D3，D5，H1受體，Ki分別為18nM，2.96nM，4.56nM，9nM和3.75nM。具有抗精神病作?[1]。IC50&TargetHumanD1ReceptorHumanD2ReceptorHumanD3ReceptorHumanD5Receptor18nM(Ki)2.96nM(Ki)4.56nM(Ki)9nM(Ki)1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEHumanH1Receptor3.75nM(Ki)體外研究Chlorprothixenebindsto5-HTreceptorswithpKisof8.3,8.5,and9.4for5-HT7,5-HT6and5-HT2,respectively[2].REFERENCES[1].YvonCoburg,etal.PotentialutilityofhistamineH3receptorantagonistpharmacophoreinantipsychotics.BioorgMedChemLett.2009Jan15;19(2):538-42.[2].BLRoth,etal.Bindingoftypicalandatypicalantipsychoticagentsto5-hydroxytryptamine-6and5-hydroxytryptamine-7receptors.JPharmacolExpTher.1994Mar;268(3):1403-10.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955