MIF-1-TFA-Pro-Leu-Gly-NH2-TFA-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEMIF-1TFACat.No.:HY-107663ASynonyms:Pro-Leu-Gly-NH2TFA;MelanostatinTFA分?式:C??H??F?N?O?分?量:398.38作?靶點(diǎn):Others作?通路:Others儲存?式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(627.54mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.5102mL12.5508mL25.1017mL5mM0.5020mL2.5102mL5.0203mL10mM0.2510mL1.2551mL2.5102mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.08mg/mL(5.22mM);Suspendedsolution;Needultrasonic2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(5.22mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.22mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性MIF-1TFA?種可抑制??素合成的抗?素，強(qiáng)效抑制StreptomycesbikiniensisNRRLB-1049和B16??素瘤細(xì)胞的??素形成。體外研究MIF-1(Melanostatin,1μM)provokedareversiblehyperpolarizationandasuppressionofspontaneousactionpotentials[2].REFERENCES[1].PRODUCTION,etal.MELANOSTATIN,ANEWMELANINSYNTHESISINHIBITOR.TheJournalofAntibiotics.1991.[2].JAValentijn,etal.Melanostatin(NPY)inhibitedelectricalactivityinfrogmelanotrophsthroughmodulationofK+,Na+andCa2+currents.JPhysiol.1994Mar1;475(2):185-95.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-