Rac-X77-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(Rac)-X77Cat.No.:HY-136298CASNo.:2144491-78-9分?式:C??H??N?O?分?量:459.58作?靶點:SARS-CoV作?通路:Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:250mg/mL(543.97mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.1759mL10.8795mL21.7590mL5mM0.4352mL2.1759mL4.3518mL10mM0.2176mL1.0879mL2.1759mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.53mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(4.53mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.53mM);ClearsolutionBIOLOGICALACTIVITY?物活性(Rac)-X77X77的外消旋體。X77SARS-CoV-2蛋?酶(SARS-CoV-2Mpro)的有效?共價鍵抑制劑。X77與SARS-CoV-2Mpro結(jié)合的Kd值為0.057μM。IC50&TargetKd:0.057μM(SARS-CoV-2Mpro)[2]體外研究X77canbindtoSARS-CoV-2Mpro(PDBcode:6W63).SARS-CoV-2Mpro(PDBcode:6W63)isthemainproteaseofSARS-CoV-2andisoneofthemostimportantdrugtargetsamongcoronaviruses[1].REFERENCES[1].SohiniChakraborti,etal.DrugRepurposingApproachTargetedAgainstMainProteaseofSARS-CoV-2Exploiting‘NeighbourhoodBehaviour’in3DProteinStructuralSpaceand2DChemicalSpaceofSmallMolecules.[2].AlexanderMAndrianov,etal.Computationaldiscoveryofsmalldrug-likecompoundsaspotentialinhibitorsofSARS-CoV-2mainprotease.JBiomolStructDynMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8