Methoxamine-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMethoxaminehydrochlorideCat.No.:HY-B1298CASNo.:61-16-5分?式:C??H??ClNO?分?量:247.72作?靶點(diǎn):AdrenergicReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:240mg/mL(968.84mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM4.0368mL20.1841mL40.3682mL5mM0.8074mL4.0368mL8.0736mL10mM0.4037mL2.0184mL4.0368mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2mg/mL(8.07mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2mg/mL(8.07mM);ClearsolutionBIOLOGICALACTIVITY?物活性Methoxaminehydrochloride?種選擇性alpha1腎上腺素能受體激動(dòng)劑。Methoxaminehydrochloride引起?管收縮和外周?管阻?增加。Methoxaminehydrochloride通過(guò)Prazosin敏感機(jī)制在兔肺動(dòng)脈顯著增加ATP、ADP和AMP的溢出，但不增加腺苷的溢出[3]。IC50&TargetNoradrenergicα1[1].體內(nèi)研究Methoxamine(0.025mg/kg;femoralvein)hydrochloridehasagreatereffectonperipheralresistancevesselsthanonWinkesselvesselsintheratsystemiccirculation[2].AnimalModel:MaleWistar-Kyotoratsweighing320-47g(basedontheexponentiallytaperedT-tubemodel)[2]Dosage:0.025mg/kgAdministration:FemoralveinResult:HadagreatereffectontheperipheralresistancevesselsthanontheWinkesselvesselsintheratsystemiccirculation.REFERENCES[1].SandersAB.Therolesofmethoxamineandnorepinephrineinelectromechanicaldissociation.AnnEmergMed.1984;13(9Pt2):835-839.[2].ChangKC.Hypertensiveeffectsofmethoxamineonarterialmechanicsinrats:analysisbasedonexponentiallytaperedT-tubemodel.EurJPharmacol.1998;350(2-3):195-202.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.