Ticarcillin-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETicarcillinCat.No.:HY-139805CASNo.:34787-01-4分?式:C??H??N?O?S?分?量:384.43作?靶點(diǎn):Antibiotic;Bacterial作?通路:Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Ticarcillin?種半合成的、?譜的、羧霉素類抗劑，對?蘭?陽性球，包括鏈球和葡萄球有活性。Ticarcillin對?多數(shù)?蘭?性?物，包括綠膿桿也有效。Ticarcillin可?于下呼吸道感染、?膚和?膚結(jié)構(gòu)感染、尿路感染和腹腔內(nèi)感染研究。體外研究Ticarcillintreatment(10mg/L;18h)showsantibacterialactivities[1].CellViabilityAssay[2]CellLine:Ps.aeruginosaConcentration:10mg/LIncubationTime:18hoursResult:ShowedtheMICforTicarcillinagainststrainbetween6.3-12.5mg/L.體內(nèi)研究Ticarcillin(Subcutaneousinjection;50,100,200mg/kg;once)treatmentshowsadose-dependentantibacterialeffect[2].Ticarcillin(Subcutaneousinjection;50,100,200mg/kg;once)treatmentshowsexcellentpharmacokineticassessment[2].AnimalModel:SwisstypemalemiceinjectedwithPs.aeruginosa[2]Dosage:50,100,200mg/kg1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAdministration:Subcutaneousinjection;50,100,200mg/kg;onceResult:Increasedeffectsignificantly(0.001<P<0.0025)withincreasingdose.AnimalModel:SwisstypemalemiceinjectedwithPs.aeruginosa[2]Dosage:50,100,200mg/kgAdministration:Subcutaneousinjection;50,100,200mg/kg;onceResult:Dose(mg/kg)AUCa(mg/kg)Kelb(h-1)T1/2(min)Ticarcillin508.76(0.72)1.57(0.18)2610026.14(0.60)1.53(0.11)2720054.56(2.90)1.47(0.12)28REFERENCES[1].CecileFormosa,etal.NanoscaleeffectsofantibioticsonP.aeruginosa.Nanomedicine.2012Jan;8(1):12-6.[2].GBvanderVoet,etal.Comparisonoftheantibacterialactivityofazlocillinandticarcillininvitroandinirradiatedneutropenicmice.JAntimicrobChemother.1985Nov;16(5):605-13.[3].OrielSpierer,etal.ComparativeactivityofantimicrobialsagainstPseudomonasaeruginosa,AchromobacterxylosoxidansandStenotrophomonasmaltophiliakeratitisisolates.BrJOphthalmol.2018May;102(5):708-712.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te