Penciclovir-sodium-VSA-671-sodium-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPenciclovirsodiumCat.No.:HY-107739CASNo.:97845-62-0Synonyms:VSA671sodium;BRL39123A;BRL39123D分?式:C??H??N?NaO?分?量:275.24作?靶點(diǎn):HSV作?通路:Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Penciclovir(VSA671)sodium?種有效的選擇性抗疹病毒(anti-herpesvirus)劑，對(duì)于HSV-1（HFEM），HSV-2（MS）的EC50值分別為0.5,0.8μg/ml。Penciclovirsodium顯?抗疹病毒活性且?細(xì)胞毒性。Penciclovirsodium可防???死亡[1][2]。IC50&TargetHSV-1HSV-20.5μg/mL(EC50)0.8μg/mL(EC50)體外研究Penciclovirsodium(0-100μg/ml)showsanti-herpesvirusactivitywithEC50sof0.5,0.8,2.4,52,100,1.2,1.6,0.9,>100μg/mlforHSV-1(HFEM),HSV-2(MS),VZV(Ellen),CMV(AD-169),BHV-1(Oxford1964),BHV-2(NewYork1),EHV-1(QuaiHals),FHV-1(B927),SVV,respectively[1].Penciclovirsodium(0-100μg/ml)showsno-toxictouninfectedhumancells[1].CellCytotoxicityAssay[1]CellLine:MRC-5,WISH,Flow4000,Flow12000,RPMI2650,WI-38,WI-38VA13,Hs68,HEp-2,RD,SCC-13,PrimarycellsConcentration:0-100μg/mlIncubationTime:Result:Showedno-toxicwithIC50sof>100,>100,100,>100,60,>100,>100,>100,>100,>100,>100,>100forMRC-5,WISH,Flow4000,Flow12000,RPMI2650,WI-38,WI-381/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEVA13,Hs68,HEp-2,RD,SCC-13,Primarycells,respectively.體內(nèi)研究Penciclovirsodium(100mg/kg;s.c.;dailyfor5days)preventesmortalityinmouse[2].AnimalModel:Three-week-oldfemaleBalb/cmice[2]Dosage:100mg/kgAdministration:S.c.;dailyfor5daysResult:Reducedvirustitresintherespiratoryorgansofbothw/t-andPR3-infectedmice.戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?MicrochemJ.2021,106587.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].M.R.Boyd,etal.Penciclovir:areviewofitsspectrumofactivity,selectivity,andcross-resistancepattern.AntiviralChemistryandChemotherapy,1993,(1):3-11.[2].delaFuenteR,etal.Theacyclicnucleosideanaloguepenciclovirisapotentinhibitorofequineherpesvirustype1(EHV-1)intissuecultureandinamurinemodel.AntiviralRes.1992May;18(1):77-89.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseo