Arg-9-acetate-Nona-L-arginine-acetate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(Arg)9acetateCat.No.:HY-P0133BSynonyms:Nona-L-arginineacetate;PeptideR9acetate分?式:C??H???N??O??分?量:1483.74SequenceShortening:RRRRRRRRR作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Protectfromlight,storedundernitrogenPowder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY?物活性(Arg)9(Nona-L-arginine)acetate?種由9個(gè)精氨酸殘組成的細(xì)胞穿透肽(CPP)。(Arg)9acetate具有神經(jīng)保護(hù)功能，在?氨酸模型中IC50值為0.78μM。IC50&TargetIC50:0.78μM(neuroprotection)[1]體外研究(Arg)9(Nona-L-arginine;5-10μM)acetateprovidessignificantneuroprotectioninadose–responsemannerfollowingglutamicacidexposure(IC50=0.78μM).Followingkainicacidexposure,(Arg)9acetateisneuroprotective,butlesseffectivethanintheglutamicacidmodel(IC50=0.81μM).(Arg)9acetatealsoshowsneuroprotectionfollowinginvitroischemia(IC50=6μM)[1].體內(nèi)研究(Arg)9(Nona-L-arginine;1?μM/kg(600?μL);i.v.;once,for30min;maleSprague–Dawleyratspermanentmiddlecerebralarterystrokemodel)acetateshowsneuroprotectiveeffectsandreducesinfarctvolume[2].AnimalModel:MaleSprague–Dawleyrats(270to320?g)permanentmiddlecerebralarterystrokemodel[2]Dosage:1μM/kg(600?μL)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAdministration:Intravenousinjection;once,over5minutesResult:Reducedsignificantiy20%ininfarctvolume.戶(hù)使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?InVitroCellDevBiol-Pl.06January2022.Seemorecustomervalidationsonwww.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955