Baloxavir-marboxil-S-033188-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBaloxavirmarboxilCat.No.:HY-109025CASNo.:1985606-14-1Synonyms:S-033188分?式:C??H??F?N?O?S分?量:571.55作?靶點(diǎn):InfluenzaVirus作?通路:Anti-infection儲(chǔ)存?式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:33.33mg/mL(58.32mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7496mL8.7481mL17.4963mL5mM0.3499mL1.7496mL3.4993mL10mM0.1750mL0.8748mL1.7496mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(4.37mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Baloxavirmarboxil(S-033188)?種選擇性的帽依賴(lài)性核酸內(nèi)切酶(endonuclease)抑制劑，Baloxavirmarboxil?種有效的抗病毒劑，具有抗甲型和?型流感病毒(influenzaA/B)活性[1]。體外研究Baloxavirmarboxilisapolymeraseacidicprotein(PA)endonucleaseinhibitor[2].戶(hù)使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?JVirol.2021Apr14;JVI0040821.?EuroSurveill.2019Mar;24(12):1900170.?FrontMicrobiol.2021Feb12;12:611958.?AntimicrobAgentsChemother.2020Jun23;64(7):e00222-20.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].FrederickGHayden,etal.BaloxavirMarboxilforUncomplicatedInfluenzainAdultsandAdolescents.NEnglJMed.2018Sep6;379(10):913-923.[2].HideyukiIkematsu,etal.BaloxavirMarboxilforProphylaxisagainstInfluenzainHouseholdContacts.NEnglJMed.2020Jul23;383(4):309-320.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37