Cloprostenol-sodium-salt-ICI-80996-sodium-salt-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECloprostenolsodiumsaltCat.No.:HY-108415CASNo.:55028-72-3Synonyms:ICI80996sodiumsalt分?式:C??H??ClNaO?分?量:446.9作?靶點:ProstaglandinReceptor作?通路:GPCR/GProtein儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗H2O:≥150mg/mL(335.65mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.2376mL11.1882mL22.3764mL5mM0.4475mL2.2376mL4.4753mL10mM0.2238mL1.1188mL2.2376mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Cloprostenolsodiumsalt(ICI80996sodiumsalt)?種合成的、有效的前列腺素類似物，具有體溶解性[1]，為PGF2αreceptor的激動劑[2]。IC50&TargetPGF2αreceptor[2]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究CloprostenolisaPGF2αreceptoragonist[2].Cloprostenol(0.1μM)counteractstheadipogeniceffectsofstatil,onbothintracellularlipidaccumulationandexpressionoftranscriptsforproadipogenicfactorsC/EBPαandPPARγaftertreatmentfor6days[2].體內(nèi)研究Cloprostenolsodiumsalt(25μg)decreasesplasmaprogesteroneinpregnantrats[1].REFERENCES[1].SalazarH,etal.Luteolyticeffectsofaprostaglandinanalogue,cloprostenol(ICI80,996),inrats:ultrastructuralandbiochemicalobservations.BiolReprod.1976May;14(4):458-72.[2].PastelE,etal.AldosereductasesinfluenceprostaglandinF2αlevelsandadipocytedifferentiationinmalemouseandhumanspecies.Endocrinology.2015May;156(5):1671-84.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;