PROTAC-FAK-degrader-1-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPROTACFAKdegrader1Cat.No.:HY-119932CASNo.:2301916-69-6分?式:C??H??F?N?O?S?分?量:996.13作?靶點(diǎn):PROTACs;FAK作?通路:PROTAC;ProteinTyrosineKinase/RTK儲(chǔ)存?式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:200mg/mL(200.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.0039mL5.0194mL10.0389mL5mM0.2008mL1.0039mL2.0078mL10mM0.1004mL0.5019mL1.0039mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5mg/mL(5.02mM);Suspendedsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥5mg/mL(5.02mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性PROTACFAKdegrader1?種于vonHippel-LindauE3配體的粘附斑激酶(FAK)的有效選擇性降解劑，IC50為6.5nM，DC50為3nM[1]。IC50&TargetIC50:6.5nM(Focaladhesionkinase)DC50:3nM(Focaladhesionkinase)[1]戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?FrontOncol.2022Apr28;12:851065.?ExpCellRes.12October2021,112868.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].CrommPM,etal.AddressingKinase-IndependentFunctionsofFakviaPROTAC-MediatedDegradation.JAmChemSoc.2018Dec12;140(49):17019-17026.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021