Efonidipine-hydrochloride-monoethanolate-NZ-105-hydrochloride-monoethanolate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEfonidipinehydrochloridemonoethanolateCat.No.:HY-12502ACASNo.:111011-76-8Synonyms:NZ-105hydrochloridemonoethanolate分?式:C??H??ClN?O?P分?量:714.18作?靶點:CalciumChannel作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗DMSO:125mg/mL(175.03mM;Needultrasonic)H2O:<0.1mg/mL(ultrasonic;warming;heatto60°C)(insoluble)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.4002mL7.0010mL14.0021mL5mM0.2800mL1.4002mL2.8004mL10mM0.1400mL0.7001mL1.4002mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(3.50mM);ClearsolutionBIOLOGICALACTIVITY?物活性Efonidipinehydrochloridemonoethanolate(NZ-105hydrochloridemonoethanolate)T型和L型鈣離?通道雙重阻斷劑。REFERENCES[1].IkedaK,etal.Efonidipine,aCa(2+)-channelblocker,enhancestheproductionofdehydroepiandrosteronesulfateinNCI-H295Rhumanadrenocorticalcarcinomacells.TohokuJExpMed.2011;224(4):263-71.[2].NakanoN,etal.Effectsofefonidipine,anL-andT-typecalciumchannelblocker,ontherenin-angiotensin-aldosteronesysteminchronichemodialysispatients.IntHeartJ.2010May;51(3):188-92.[3].SuzukiS,etal.BeneficialeffectsofthedualL-andT-typeCa2+channelblockerefonidipineoncardiomyopathichamsters.CircJ.2007Dec;71(12):1970-6.[4].LeeTS,etal.Actionsofmibefradil,efonidipineandnifedipineblockofrecombinantT-andL-typeCachannelswithdistinctinhibitorymechanisms.Pharmacology.2006;78(1):11-20.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.