Olodanrigan-EMA401-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEOlodanriganCat.No.:HY-13106CASNo.:1316755-16-4Synonyms:EMA401;PD-126055分?式:C??H??NO?分?量:507.58作?靶點:AngiotensinReceptor作?通路:GPCR/GProtein儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:≥34mg/mL(66.98mM)H2O:0.1mg/mL(0.20mM;Needultrasonic)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.9701mL9.8507mL19.7013mL5mM0.3940mL1.9701mL3.9403mL10mM0.1970mL0.9851mL1.9701mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性O(shè)lodanrigan(EMA401)?個?選擇性、?服活性、外周受限的?管緊張素Ⅱ類型2受體(AT2R)拮抗劑。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE可?于神經(jīng)性疼痛的研究。Olodanrigan(EMA401)的緩解疼痛作?似乎包括抑制增強的AngII/AT2R誘導的p38和p42/p44MAPK激活，從?抑制DRG神經(jīng)元的過度興奮性和DRG神經(jīng)元的萌發(fā)。體內(nèi)研究EMA401(10?mg/kg;p.o.)resultsinasignificantattenuationofthetapowerandincreaseinpawwithdrawallatencies(PWL)inratsatday14afterchronicconstrictioninjury(CCI)[4].戶使?本產(chǎn)品發(fā)表的科研?獻?JPharmacolSci.146(2021)121-124.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].RiceASetal.EMA401,anorallyadministeredhighlyselectiveangiotensinIItype2receptorantagonist,asanoveltreatmentforpostherpeticneuralgia:arandomised,double-blind,placebo-controlledphase2clinicaltrial.Lancet.2014May10;383(9929[2].AnandUetal.MechanismsunderlyingclinicalefficacyofAngiotensinIItype2receptor(AT2R)antagonistEMA401inneuropathicpain:clinicaltissueandinvitrostudies.MolPain.2015Jun26;11:38.[3].SuguruKoyama,etal.AnElectroencephalographyBioassayforPreclinicalTestingofAnalgesicEfficacy.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-