事件相關(guān)電位入門課件

CognitiveNeuroscience

&ERPs（Eventrelatedpotentials）認知神經(jīng)科學—CognitiveNeuroscience是一門研究人腦高級功能的學科，它是認知科學與神經(jīng)腦科學結(jié)合的產(chǎn)物。認知神經(jīng)科學的研究目的在于闡明認知活動的腦機制，其學科分支包括認知神經(jīng)心理學、認知心理生理學、認知生理心理學、認知神經(jīng)生物學、計算神經(jīng)科學。認知神經(jīng)科學Event-relatedpotentialsEvent-relatedbrainpotentials

凡是外加一種特定的刺激，作用于感覺系統(tǒng)或腦的某一部位，在給予刺激或撤消刺激時，在腦區(qū)引起的電位變化。

*刺激缺失事件相關(guān)（腦）電位ERP的學術(shù)位置屬于心理生理學（psychophysiology）范疇心理生理學以心理因素為自變量，以生理指標為應(yīng)變量，一般以人為被試。生理心理學（physiologicalpsychology）以生理變化為自變量，以心理因素為應(yīng)變量，一般以動物為被試。心理生理學是從生理心理學中分離出來的，同屬認知神經(jīng)科學。認知神經(jīng)科學是當前腦科學界頗受關(guān)注的領(lǐng)域，ERP是其中的重要組成部分。事件相關(guān)（腦）電位ERPs研究成分研究應(yīng)用研究特點及其影響因素起源及產(chǎn)生機制心理生理臨床應(yīng)用特因條件功能評估注意、記憶、語言加工、運動知覺等神經(jīng)精神科、昏迷愈后、輔助診斷等航空、航天、航海、惡劣環(huán)境條件等駕駛疲勞、功能評估、音樂認知能力、健康評估等ERPs的研究分類Oddball兩種刺激物三種刺激物新異刺激物的插入標準刺激(Standard)偏差刺激(Deviant)靶刺激(Target)非靶刺激(non-Target)標準模式缺失刺激為靶P3aP3bStandardDeviant(Tarkka&Stokic,1998)Standard(DAVIDE.J.LINDEN.Review,2004)StandardDeviantNovelAuditoryP3b/P3aindepressedpatientsNovelOddballParadigmTarget2000Hz15%Non-Target1000Hz70%AuditoryNovelStimuli15%PressAuditoryP3aCortexCurrentDensityNormal(358ms)

Depressed(358ms)MGFPPeakNormal－Depressed抑郁癥患者（右）額葉認知功能障礙(LvJ,ZhaoL,etal,2010)BehavioralInhibitingResponsesIftheusualtarget-detectiontaskisinvertedsothatthesubjectrespondstothestandardstimuliandwithholdsresponsefromthetarget,theN2wavetotheno-gostimulusisincreasedinamplitude(Eimer,1993)andtheP300ismorefrontallydistributed(e.g.,Hillyard,etal,1976;Robertsetal.,1994;Falkensteinetal,1995)(BWZhang,L.Zhao,X.Jing.2007)FacingsomeproblemsofemotionalregulationatthestageofcopingwiththeconflictinInternetAddictionpatients-200600uV2.5-2.5FZmsIApatientsNormalNogoPZGoP3goP3nogoN2nogo(Dang,etal，unpublisheddata)山川山川面孔識別的心理生理機制（Carbon&Leder,2005）Thatcherfaces（Carbon&Leder,2005）（Carbon&Leder,2005）FunctionalcharacteristicsoftheN170-effectNotsensitivetofacefamiliarity(Bentin&Deouell,2000).Sensitivetolocalmorethantoglobalinformationandnotadverselyaffectedbyinhibitingconfiguralprocessing:Largereffectforisolatedeyesandfacecomponentsthanforfullfaces(Bentinetal.,1996,Bentin&Aviezer,unpublished;Bentin&McCarthy,unpublished).Notsignificantlyreducedbyrandomrelocationofinnercomponents(Bentinetal.,1996).Notreduced(indeedenhanced)byfaceinversion(Bentinetal.1996;Sagiv&Bentin,2001;Rossionetal,1999;2000)Despiteglobalfaceconfiguration,itiseliminatedwhenlocalinformationisnotphysiognomic(Bentin,Golland,&,Moscovitch,2003).HypotheticalroleoftheperceptualmechanismassociatedwiththeN170-effectTheN170-effectisassociatedwithan“early”perceptualmechanismtunedtodetectvisualfeaturesthatarecharacteristictoafacephysiognomy.Itsrolemightbetotriggertheface-characteristicstructuralencodingprocesseswhenpertinentstimuliarepresentinthevisualfield.N170inversioneffectoffaces(Gao,etal,2009)(ZhaoL.&LiJ.,2006)ExpressionMismatchNegativity（EMMN）(ZhaoL.&LiJ.,2006)EMMNindepressionpatients-100400msuV-1.51.5T6

NormalDepressionEMMNChang,etal.2010近期研究Visualperception、UnconsciousnessprocessingInternetAddictionAutism&DepressionBurnout運動員、人才選拔、職業(yè)健康、青少年心理健康等Bindingtheory……ThankyouforyourattentionFamiliarityeffectsonN170LeftMastoid8005V-5V0400millisecondsRightMastoid0400milliseconds

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BUTTERFLIES-5μV+5μVUnfamiliarFamiliarBentin&Deouell,2000N170elicitedbyfacesandfacecomponentsLeftMastoid-550RightMastoid50-5μV02004006008000200400600800Milliseconds-440μV02004006008000200400600800Milliseconds-440Bentin&McCarthy,unpublished0200400milliseconds05-510LeftMastoid.VRightMastoid0200400milliseconds+2.5-2.5N170(in)sensitivitytothefaceconfigurationBentinetal.,19960100200300400MillisecondsIM20

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