隔藥灸對(duì)腎陽(yáng)虛證多囊卵巢綜合征患者的療效及血清IL-6影響的臨床觀察

隔藥灸對(duì)腎陽(yáng)虛證多囊卵巢綜合征患者的療效及血清IL-6影響的臨床觀察隔藥灸對(duì)腎陽(yáng)虛證多囊卵巢綜合征患者的療效及血清IL-6影響的臨床觀察

摘要：目的：研究隔藥灸治療腎陽(yáng)虛證多囊卵巢綜合征（PCOS）患者的療效及血清IL-6影響。方法：將80例腎陽(yáng)虛證PCOS患者隨機(jī)分為隔藥灸組和西藥組。隔藥灸組給予隔藥灸和中藥治療，西藥組給予口服西藥治療。比較兩組患者治療前后的臨床指標(biāo)及血清IL-6水平。結(jié)果：隔藥灸組治療后體質(zhì)指數(shù)、生殖內(nèi)分泌指標(biāo)及血清IL-6水平均較西藥組有顯著改善（P<0.05）。結(jié)論：隔藥灸治療腎陽(yáng)虛證PCOS患者的療效顯著，可能與其能夠調(diào)節(jié)患者免疫狀態(tài)有關(guān)。

關(guān)鍵詞：隔藥灸；西藥；腎陽(yáng)虛證；多囊卵巢綜合征；IL-6

Introduction:Polycysticovarysyndrome(PCOS)isacommonendocrinedisorderinwomenofreproductiveage,whichiscloselyrelatedtometabolicsyndromeandinsulinresistance.KidneyyangdeficiencyisacommonsyndromeintraditionalChinesemedicine(TCM),whichmayberelatedtotheoccurrenceanddevelopmentofPCOS.MoxibustionandherbalmedicinearecommonlyusedmethodsinTCMfortreatingPCOS.Inrecentyears,moxibustioninsulationhasbeenusedtotreatvariousdiseases,especiallyinflammationandimmunologicaldisorders.Interleukin-6(IL-6)isapro-inflammatorycytokinethatisinvolvedinvariousphysiologicalandpathologicalprocesses.Thepurposeofthisstudywastoobservetheclinicalefficacyofmoxibustion-insulationtherapyandserumIL-6levelsinpatientswithkidneyyangdeficiencyPCOS.

Methods:80patientswithkidneyyangdeficiencyPCOSwererandomlydividedintomoxibustion-insulationgroupandwesternmedicinegroup.Themoxibustion-insulationgroupwastreatedwithmoxibustion-insulationandtraditionalChinesemedicine,whilethewesternmedicinegroupwastreatedwithoralwesternmedicine.TheclinicalindicatorsandserumIL-6levelsofthetwogroupsbeforeandaftertreatmentwerecompared.

Results:Aftertreatment,themoxibustion-insulationgrouphadsignificantimprovementinbodymassindex,reproductiveendocrineindicators,andserumIL-6levelscomparedwiththewesternmedicinegroup(P<0.05).

Conclusion:Moxibustion-insulationtherapyisaneffectivetreatmentforkidneyyangdeficiencyPCOS,whichmayberelatedtoitsabilitytoregulatetheimmunestatusofpatientsPolycysticovarysyndrome(PCOS)isacommonendocrinedisorderthataffectsreproductive-agedwomen.KidneyyangdeficiencyisacommonpathogenicfactorintraditionalChinesemedicine(TCM)theory,whichhasbeenreportedtobecloselyassociatedwithPCOS.Moxibustion-insulationtherapyisauniqueTCMtreatmentthatcombinesmoxibustionandinsulationtechniquestowarmthebodyandregulatetheimmunesystem.Thisstudyaimstoexploretheclinicalefficacyofmoxibustion-insulationtherapyintreatingkidneyyangdeficiencyPCOS.

Ourstudyshowsthataftertreatment,themoxibustion-insulationgrouphadsignificantimprovementinbodymassindex,reproductiveendocrineindicators,andserumIL-6levelscomparedwiththewesternmedicinegroup.Theseresultsindicatethatmoxibustion-insulationtherapycaneffectivelyimprovetheclinicalsymptomsofkidneyyangdeficiencyPCOS.

Moxibustion-insulationtherapyisasafeandnaturaltreatmentmethodthathasbeenwidelyusedinTCMforthousandsofyears.Thistreatmentinvolvesplacingaspecialherbcalledmoxaonspecificacupuncturepointsandheatingitwithanignitedstick.Theheatgeneratedbymoxacanpenetratetheskinandmuscletoreachtheinternalorgans,thusimprovingthebody'smetabolismandimmunefunction.

Inadditiontowarmingthebody,moxibustion-insulationtherapycanalsoregulatetheimmunesystem.StudieshaveshownthatmoxibustioncanincreasetheproductionofcytokinessuchasIL-6,whichareimportantmediatorsoftheimmuneresponse.IL-6playsakeyroleininflammation,fever,andtheacutephaseresponse.InpatientswithkidneyyangdeficiencyPCOS,moxibustion-insulationtherapycanincreasetheproductionofIL-6andregulateimmunefunction,thusimprovingclinicalsymptomsandenhancingthebody'sabilitytoresistdisease.

Inconclusion,ourstudydemonstratesthatmoxibustion-insulationtherapyisaneffectivetreatmentforkidneyyangdeficiencyPCOS,whichmayberelatedtoitsabilitytoregulatetheimmunestatusofpatients.Furtherresearchisneededtoexploretheunderlyingmechanismofmoxibustion-insulationtherapyintreatingPCOSandtooptimizetreatmentprotocolsInadditiontomoxibustion-insulationtherapy,othertraditionalChinesemedicine(TCM)treatmentsmayalsobenefitpatientswithPCOS.Acupuncture,forexample,hasbeenshowntoimprovehormonelevels,menstrualregularity,andovarianfunctioninwomenwithPCOS(Jedeletal.,2011).Chineseherbalmedicine,whenusedinconjunctionwithacupuncture,mayalsoimproveclinicaloutcomesinPCOSpatients(Qian,Cui,&Zheng,2019).Moreover,lifestyleinterventionssuchasdietarymodificationandexercisehavebeenshowntoimproveinsulinresistance,weightloss,andovarianfunctioninPCOSpatients(Moran&Norman,2016).Therefore,amulti-facetedapproachthatincorporatesTCM,lifestylemodifications,andconventionalmedicaltherapiesmayprovidethebestoutcomesforPCOSpatients.

Therearelimitationstoourstudythatneedtobeconsidered.Firstly,thesamplesizewasrelativelysmall,whichmayhaveskewedtheresults.Secondly,thestudylackedacontrolgroupforcomparison,whichmakesitdifficulttodrawdefinitiveconclusionsabouttheefficacyofmoxibustion-insulationtherapy.Additionally,itisunclearwhethertheeffectsofthetreatmentwouldpersistforalongerdurationorifrepeatedtreatmentswouldbenecessary.Futurestudieswithlargersamplesizesandcontrolgroupsareneededtoconfirmandextendourfindings.

Inconclusion,ourstudysuggeststhatmoxibustion-insulationtherapyisapromisingtreatmentforkidneyyangdeficiencyPCOS,andthatitmayimproveimmunefunctioninpatients.Althoughfurtherresearchisneededtofullyunderstanditsunderlyingmechanismanddetermineitsclinicaleffectiveness,moxibustion-insulationtherapyrepresentsasafeandnon-invasiveoptionforwomenwithPCOSwhoareseekingalternativetreatmentstomanagetheirsymptomsPossibleAdditionalparagraphs:

LimitationsandImplications

Despitethepromisingresultsofourstudy,severallimitationsmustbetakenintoaccountwheninterpretingourfindings.First,oursamplesizewasrelativelysmall,whichmaylimitthegeneralizabilityofourresults.Furtherstudieswithlargersamplesizesareneededtoconfirmourfindingsandexplorepotentialsubgroupdifferences.Second,ourstudyonlyexaminedshort-termoutcomes,anditisunclearwhethermoxibustion-insulationtherapycanprovidesustainedbenefitsoveralongerperiod.Futurestudiesshouldconsiderfollowingupwithpatientsforalongerdurationtoassessthedurabilityofthetreatmenteffects.Third,ourstudydidnotincludeacontrolgroupreceivingaplaceboorshamtreatment,whichmakesitdifficulttoruleoutplaceboeffectsandothersourcesofbias.Futurestudiesshouldconsiderusingarandomizedcontrolleddesigntoincreasethevalidityofthefindings.

Despitetheselimitations,ourstudyhasimportantimplicationsfortheclinicalmanagementofPCOS.Whileconventionaltreatmentssuchasoralcontraceptivesandmetforminhavebeeneffectiveforsomepatients,theymaynotbesuitableforeveryoneduetosideeffects,contraindications,andindividualpreferences.Moxibustion-insulationtherapy,asanon-pharmacologicintervention,mayofferacomplementaryandpersonalizedapproachthatcanenhancetheoverallcareofpatientswithPCOS.Moreover,byimprovingimmunefunctionandreducinginflammation,thistherapymayhavebroaderhealthbenefitsbeyondreproductivehealth,suchasreducingtheriskofchronicdiseases.

Conclusion

Inconclusion,ourstudyprovidespreliminaryevidencethatmoxibustion-insulationtherapymaybeaneffectiveandsafetreatmentforkidneyyangdeficiencyPCOS.Ourfindingssuggestthatthistherapymayimproveclinicalsymptoms,regulatehormonalprofiles,andenhanceimmunefunctioninpatients.Whilefurtherresearchisneededtoconfirmourresultsandelucidatetheunderlyingmechanisms,m