MARK4-inhibitor-2-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMARK4inhibitor2Cat.No.:HY-154986分?式:C??H??N?O?分?量:542.63作?靶點:AMPK作?通路:Epigenetics;PI3K/Akt/mTOR儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性MARK4inhibitor2微管親和調(diào)節(jié)激酶4(MARK4)的抑制劑，對其Km值為6.3×107，IC50為0.82μM。MARK4inhibitor2抑制癌細胞的?長，可?于癌癥研究。IC50&TargetIC50:0.82μM(MARK4)[1]Km:6.3×107[1]體外研究MARK4inhibitor2(Compound23a)(0-20μM;24hour)inhibitsthegrowthofHeLa,U87MG,MDA-MB-435,U251andHGFscellswithEC50srangingfrom1.76μMto7.98μM[1].CellViabilityAssay[1]CellLine:HeLa,U87MG,MDA-MB-435,U251,HGFscellsConcentration:0-20μMIncubationTime:24hoursResult:InhibitedthegrowthofhumancellswithEC50sof2.13,4.13,1.76,7.98,3.55μMforHeLa,U87MG,MDA-MB-435,U251,HGFscells,respectively.Decreasedtheproliferationofhumancancercellsinthelowmicromolarrange;alsoaffectsthenon-cancerousHGFcells.REFERENCES[1].MariaVoura,et.al.Synthesis,StructuralModification,andBioactivityEvaluationofSubstitutedAcridonesasPotentMicrotubuleAffinity-RegulatingKinase4InhibitorsACSPharmacology&TranslationalScience20236(7),1052-1074.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02