時(shí)間藥理學(xué)與臨床用藥剖析課件

時(shí)間藥理學(xué)與臨床用藥chronopharmacologychronobiologyCLINICALPHARMACOLOGYOPLI時(shí)間藥理學(xué)與臨床用藥1生物節(jié)律的概念晝夜節(jié)律(circadianrhythm,近日節(jié)律)■短日節(jié)律(ultradian)如呼吸、脈搏等長日節(jié)律(infradian)近周節(jié)律(circaseptan)近月節(jié)律(circamensual)近年節(jié)律(circannual)CLINICALPHARMACOLOGYOPLI生物節(jié)律的概念2表L6·!常見生物節(jié)的周期律率周翔范實(shí)鮮超日節(jié)律(ultnuliauhrlm新生兒睡虱-黨凰父哲近似2h節(jié)律{cimhutealmilam1.7上I)h快、慢詖聯(lián)交1.52h近似半日節(jié)bvh〔12±上海津物的彩種潮彩節(jié)律為124h近日節(jié)(circadianhbm)2~28h無投時(shí)囚了件下人的體溫節(jié)律2h夜節(jié)律〔diclrhytlur23.8~24.2h多種生物,人的各種塵埋功能等亞山節(jié)缽〔infradian>2Rh雌性人鼠發(fā)悄間約4d近似問節(jié)律人血清皮質(zhì)醇濃度,蒂館排反近似月節(jié)律〔cr和alruthin)(305)d女性月經(jīng)期等近似年節(jié)個(gè)(curtanruumlrtiwthum(365±60h血力物的冬脹、艾些價(jià)類游等CLINICALPHARMACOLOGYOPLI表L6·!常見生物節(jié)的周期3生物節(jié)律的概念節(jié)律異?！鱿辔灰苿印鎏崆?、延遲、倒置、反相節(jié)律同步或失同步授時(shí)因子(zeitgeber)同步因子(Synchroniger)CLINICALPHARMACOLOGYOPLI生物節(jié)律的概念4人體功能、疾病的晝夜節(jié)律心血管系統(tǒng)血壓、心率冠狀動脈血流量血小板聚集■心肌梗塞與心源性猝死心絞痛CLINICALPHARMACOLOGYOPLI人體功能、疾病的晝夜節(jié)律5血壓與心率的晝夜節(jié)律12151821243dipper時(shí)間(h)血壓與心率的晝夜節(jié)律6血小板聚集及血漿腎上腺素濃度○血小板聚集性血漿Adr濃度8爛騷75清落3時(shí)間血小板聚集及血漿腎上腺素濃度7心肌梗塞發(fā)病的晝夜節(jié)律求時(shí)間(hLINCAI了HARMIALULUUYoPI心肌梗塞發(fā)病的晝夜節(jié)律8肌梗塞的晝夜節(jié)律703例時(shí)間(hCLINICALPHARMACOLOGYOPLI肌梗塞的晝夜節(jié)律9X(g/100m)漿的塞晝化夜可節(jié)的律松水平VIACOLOGYOPLIX(g/100m)10時(shí)間藥理學(xué)與臨床用藥剖析課件11時(shí)間藥理學(xué)與臨床用藥剖析課件12時(shí)間藥理學(xué)與臨床用藥剖析課件13時(shí)間藥理學(xué)與臨床用藥剖析課件14時(shí)間藥理學(xué)與臨床用藥剖析課件15時(shí)間藥理學(xué)與臨床用藥剖析課件16時(shí)間藥理學(xué)與臨床用藥剖析課件17時(shí)間藥理學(xué)與臨床用藥剖析課件18時(shí)間藥理學(xué)與臨床用藥剖析課件19時(shí)間藥理學(xué)與臨床用藥剖析課件20時(shí)間藥理學(xué)與臨床用藥剖析課件21時(shí)間藥理學(xué)與臨床用藥剖析課件22時(shí)間藥理學(xué)與臨床用藥剖析課件23時(shí)間藥理學(xué)與臨床用藥剖析課件24時(shí)間藥理學(xué)與臨床用藥剖析課件25時(shí)間藥理學(xué)與臨床用藥剖析課件26時(shí)間藥理學(xué)與臨床用藥剖析課件27時(shí)間藥理學(xué)與臨床用藥剖析課件28時(shí)間藥理學(xué)與臨床用藥剖析課件29時(shí)間藥理學(xué)與臨床用藥剖析課件30時(shí)間藥理學(xué)與臨床用藥剖析課件31時(shí)間藥理學(xué)與臨床用藥剖析課件32時(shí)間藥理學(xué)與臨床用藥剖析課件33時(shí)間藥理學(xué)與臨床用藥剖析課件34時(shí)間藥理學(xué)與臨床用藥剖析課件35時(shí)間藥理學(xué)與臨床用藥剖析課件36時(shí)間藥理學(xué)與臨床用藥剖析課件37時(shí)間藥理學(xué)與臨床用藥剖析課件38時(shí)間藥理學(xué)與臨床用藥剖析課件39時(shí)間藥理學(xué)與臨床用藥剖析課件40時(shí)間藥理學(xué)與臨床用藥剖析課件41時(shí)間藥理學(xué)與臨床用藥剖析課件42時(shí)間藥理學(xué)與臨床用藥剖析課件43時(shí)間藥理學(xué)與臨床用藥剖析課件44時(shí)間藥理學(xué)與臨床用藥剖析課件45時(shí)間藥理學(xué)與臨床用藥剖析課件46時(shí)間藥理學(xué)與臨床用藥剖析課件47時(shí)間藥理學(xué)與臨床用藥剖析課件48時(shí)間藥理學(xué)與臨床用藥剖析課件49時(shí)間藥理學(xué)與臨床用藥剖析課件50時(shí)間藥理學(xué)與臨床用藥剖析課件51時(shí)間藥理學(xué)與臨床用藥剖析課件52時(shí)間藥理學(xué)與臨床用藥剖析課件53時(shí)間藥理學(xué)與臨床用藥剖析課件54時(shí)間藥理學(xué)與臨床用藥剖析課件55時(shí)間藥理學(xué)與臨床用藥剖析課件56時(shí)間藥理學(xué)與臨床用藥剖析課件57時(shí)間藥理學(xué)與臨床用藥剖析課件58時(shí)間藥理學(xué)與臨床用藥剖析課件59時(shí)間藥理學(xué)與臨床用藥剖析課件60時(shí)間藥理學(xué)與臨床用藥剖析課件61時(shí)間藥理學(xué)與臨床用藥剖析課件62時(shí)間藥理學(xué)與臨床用藥剖析課件63時(shí)間藥理學(xué)與臨床用藥剖析課件64時(shí)間藥理學(xué)與臨床用藥剖析課件65時(shí)間藥理學(xué)與臨床用藥剖析課件66時(shí)間藥理學(xué)與臨床用藥剖析